STL1267
Modify Date: 2024-04-08 09:55:43
STL1267 structure
|
Common Name | STL1267 | ||
|---|---|---|---|---|
| CAS Number | 1429024-58-7 | Molecular Weight | 322.75 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H11ClN4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of STL1267STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a Ki value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1[1]. |
| Name | STL1267 |
|---|
| Description | STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a Ki value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1[1]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 0.16 µM (REV-ERBα)[1] |
| In Vitro | STL1267 (5 µM; 24 h) 在 HepG2 细胞中降低 BMAL1 的表达并增加 Mtnd1、Mtco1、Vicad、Lcad、Scad、Lkb1、Sirt1、Nampt、Ppargc1a 的基因表达[1]。 Cell Viability Assay[1] Cell Line: HepG2, C2C12 cells Concentration: 0-20 µM Incubation Time: 24 h Result: Showed no adverse effects on cell viability up to the maximum dose examined 20 µM. RT-PCR[1] Cell Line: HepG2 cells Concentration: 5 µM Incubation Time: 24 h Result: Decreased the gene expression of BMAL1, increased the gene expression of Mtnd1, Mtco1, Vicad, Lcad, Scad, Lkb1, Sirt1, Nampt, Ppargc1a. |
| In Vivo | STL1267 (50 mg/kg; i.p.; once) 在小鼠体内有效抑制 BMAL1 的表达[1]。 Animal Model: 6-8 weeks, male C57Bl/6 J mice[1] Dosage: 50 mg/kg Administration: I.p.; once Result: Showed a plasma half-life of 1.6 h, effectively suppressed BMAL1 expression in the liver at 12 h post-administration. |
| References |
| Molecular Formula | C17H11ClN4O |
|---|---|
| Molecular Weight | 322.75 |