16-Hydroxycleroda-3,13-dien-15,16-olide

Modify Date: 2025-09-19 12:59:46

16-Hydroxycleroda-3,13-dien-15,16-olide structure	Common Name	16-Hydroxycleroda-3,13-dien-15,16-olide
	CAS Number	141979-19-3	Molecular Weight	318.45
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₃₀O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 16-Hydroxycleroda-3,13-dien-15,16-olide

16-Hydroxycleroda-3,13-dien-15,16-olide (16ξ-Hydroxycleroda-3,13-dien-15,16-olide; HCD), a clerodane diterpene, is a potent serine protease dipeptidyl peptidase 4 (DPP-4) inhibitor. 16-Hydroxycleroda-3,13-dien-15,16-olide down-regulates LPS-induced ERK phosphorylation in myocyte but blocks GLP-1 induced PKA expression. 16-Hydroxycleroda-3,13-dien-15,16-olide exhibits hypolipidemic, hepatoprotective, hypoglycemic efficacy[1].

Name	16-Hydroxycleroda-3,13-dien-15,16-olide

Description	16-Hydroxycleroda-3,13-dien-15,16-olide (16ξ-Hydroxycleroda-3,13-dien-15,16-olide; HCD), a clerodane diterpene, is a potent serine protease dipeptidyl peptidase 4 (DPP-4) inhibitor. 16-Hydroxycleroda-3,13-dien-15,16-olide down-regulates LPS-induced ERK phosphorylation in myocyte but blocks GLP-1 induced PKA expression. 16-Hydroxycleroda-3,13-dien-15,16-olide exhibits hypolipidemic, hepatoprotective, hypoglycemic efficacy[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase Research Areas >> Metabolic Disease
References	[1]. Po-Kai Huang, et al. Polyalthia Clerodane Diterpene Potentiates Hypoglycemia via Inhibition of Dipeptidyl Peptidase 4. Int J Mol Sci. 2019 Jan 27;20(3):530.

Molecular Formula	C₂₀H₃₀O₃
Molecular Weight	318.45
InChIKey	LVSCWEDTMWAASP-UHFFFAOYSA-N
SMILES	CC1=CCCC2C1(C)CCC(C)C2(C)CCC1=CC(=O)OC1O
Storage condition	2-8℃

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16-Hydroxycleroda-3,13-dien-15,16-olide

Use of 16-Hydroxycleroda-3,13-dien-15,16-olide

Names

16-Hydroxycleroda-3,13-dien-15,16-olide Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.