GC376

Modify Date: 2024-01-13 13:04:52

GC376 structure	Common Name	GC376
	CAS Number	1416992-39-6	Molecular Weight	507.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₃₀N₃NaO₈S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GC376

GC376 is a novel, first-in-class, small molecule protease inhibitor with a favorable therapeutic index demonstrated in preclinical studies. A common feature of viruses in the picornavirus-like supercluster (including coronaviruses) is a 3C or 3C-like protease (3Cpro or 3CLpro, respectively) responsible for viral replication. Viruses in this family include human coronavirus 229E, transmissible gastroenteritis virus of swine (TGEV), murine hepatitis virus (MHV), bovine coronavirus (BCV), feline infectious peritonitis virus (FIPV), severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East Respiratory Syndrome (MERS) and COVID-19 (SARS-CoV-2). GC376 has been shown to be a potent inhibitor of this protease across all coronaviruses with a high therapeutic index.