N-Desmethyl Sildenafil

Modify Date: 2024-01-03 17:17:21

N-Desmethyl Sildenafil structure	Common Name	N-Desmethyl Sildenafil
	CAS Number	139755-82-1	Molecular Weight	460.55
	Density	1.44g/cm3	Boiling Point	685.7ºC at 760 mmHg
	Molecular Formula	C₂₁H₂₈N₆O₄S	Melting Point	158-160ºC
	MSDS	N/A	Flash Point	368.5ºC

Use of N-Desmethyl Sildenafil

N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor[1][2].

Name	N-Desmethyl Sildenafil
Synonym	More Synonyms

Description	N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
In Vitro	N-Desmethyl Sildenafil increases the amplitude of electroretinogram (ERG) recorded from the dark-adapted isolated rat retina, most probably through the enhancement of the photoreceptor cell response[1]. The formation of N-Desmethyl Sildenafil is examined using CYP3A supersomes co-expressing human P450 oxidoreductase and cytochrome b5. N-Desmethyl Sildenafil is catalyzed by CYP3A4, CYP3A5, and to a lesser extent by CYP3A7[2].
References	[1]. Péter Barabás, et al. Sildenafil, N-desmethyl-sildenafil and Zaprinast enhance photoreceptor response in the isolated rat retina. Neurochem Int. 2003 Nov;43(6):591-5. [2]. Rikako Takahiro, et al. Contribution of CYP3A isoforms to dealkylation of PDE5 inhibitors: a comparison between sildenafil N-demethylation and tadalafil demethylenation. Biol Pharm Bull. 2015;38(1):58-65.

Density	1.44g/cm3
Boiling Point	685.7ºC at 760 mmHg
Melting Point	158-160ºC
Molecular Formula	C₂₁H₂₈N₆O₄S
Molecular Weight	460.55
Flash Point	368.5ºC
Exact Mass	460.18900
PSA	130.59000
LogP	2.61620
Vapour Pressure	1.17E-18mmHg at 25°C
Index of Refraction	1.683

5-(2-ethoxy-5-piperazin-1-ylsulfonylphenyl)-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: N-Desmethyl Sildenafil
Price: ￥5066.0/10g ￥3036.0/5g ￥1006.0/1g ￥406.0/250mg
Purity: 95.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: N-Desmethyl Sildenafil
Price: $Inquiry/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao

Get all suppliers and price by the below link:

N-Desmethyl Sildenafil suppliers

N-Desmethyl Sildenafil price

N-Desmethyl Sildenafil

Use of N-Desmethyl Sildenafil

Names

N-Desmethyl Sildenafil Biological Activity

Chemical & Physical Properties

Synonyms