27-O-(tert-Butyldimethylsilyl)withaferin A

Modify Date: 2024-01-18 13:49:47

27-O-(tert-Butyldimethylsilyl)withaferin A Structure
27-O-(tert-Butyldimethylsilyl)withaferin A structure
 Common Name 27-O-(tert-Butyldimethylsilyl)withaferin A
CAS Number 1392820-18-6 Molecular Weight 584.86
Density N/A Boiling Point N/A
Molecular Formula C34H52O6Si Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 27-O-(tert-Butyldimethylsilyl)withaferin A


27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells[1].

 Names

Name 27-O-(tert-Butyldimethylsilyl)withaferin A

  Biological Activity

Description 27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells[1].
Related Catalog
In Vitro 27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a; 32 μM; 4-8 hours) inhibits caspase-3 activity in HeLa cells[1]. 27-O-(tert-Butyldimethylsilyl)withaferin A (48 hours) shows antiproliferative activity against HeLa, A-549, MCF-7, and Vero cells with IC50 values of 0.9 μM, 1.5 μM, 0.7 μM, and 0.7 μM, respectively[1].
References

[1]. Gabriel G Llanos, et al. Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells. Eur J Med Chem. 2012 Aug;54:499-511.

 Chemical & Physical Properties

Molecular Formula C34H52O6Si
Molecular Weight 584.86
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Chemsrc provides CAS#:1392820-18-6 MSDS, density, melting point, boiling point, structure, etc. Its name is 27-O-(tert-Butyldimethylsilyl)withaferin A>> amp version: 27-O-(tert-Butyldimethylsilyl)withaferin A

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