Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite

Modify Date: 2024-01-23 11:05:37

Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite structure	Common Name	Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
	CAS Number	1391728-01-0	Molecular Weight	344.39
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₂₉N₂O₄P	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite

Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
Synonym	More Synonyms

Description	Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₁₆H₂₉N₂O₄P
Molecular Weight	344.39

MFCD28142480