(2R)-Octyl-α-hydroxyglutarate

Modify Date: 2024-01-10 15:54:42

(2R)-Octyl-α-hydroxyglutarate structure	Common Name	(2R)-Octyl-α-hydroxyglutarate
	CAS Number	1391194-67-4	Molecular Weight	260.327
	Density	1.1±0.1 g/cm3	Boiling Point	420.5±35.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₂₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	152.3±19.4 °C

Use of (2R)-Octyl-α-hydroxyglutarate

(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a modified form of D-isomer 2-Hydroxyglutarate.

Name	(2R)-Octyl-α-hydroxyglutarate
Synonym	More Synonyms

Description	(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a modified form of D-isomer 2-Hydroxyglutarate.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
In Vitro	Treatment of IDH1-WT HeLa cells with (2R)-Octyl-α-hydroxyglutarate, a modified form of 2-Hydroxyglutarate with high cellular uptake, results in a dose-dependent increase in DSBs in log-phase cells. It has been used to examine the contribution of D-2-Hydroxyglutarate to the oxidative mitochondrial processes of IDH1-mutated cancer cells[1].
References	[1]. Sulkowski PL, et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologousrecombination and induces PARP inhibitor sensitivity. Sci Transl Med. 2017 Feb 1;9(375).

Density	1.1±0.1 g/cm3
Boiling Point	420.5±35.0 °C at 760 mmHg
Molecular Formula	C₁₃H₂₄O₅
Molecular Weight	260.327
Flash Point	152.3±19.4 °C
Exact Mass	260.162384
LogP	3.03
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.473

(4R)-4-Hydroxy-5-(octyloxy)-5-oxopentanoic acid

Pentanedioic acid, 2-hydroxy-, 1-octyl ester, (2R)-

MFCD29045545