pVXc-486
Modify Date: 2025-11-26 17:44:28
pVXc-486 structure
|
Common Name | pVXc-486 | ||
|---|---|---|---|---|
| CAS Number | 1384984-20-6 | Molecular Weight | 552.40 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H24FN6Na2O6P | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of pVXc-486pVXc-486 is an orally active and potent phosphate prodrug of VXc-486. pVXc-486 has potent bactericidal activities in vivo[1]. |
| Name | pVXc-486 |
|---|
| Description | pVXc-486 is an orally active and potent phosphate prodrug of VXc-486. pVXc-486 has potent bactericidal activities in vivo[1]. |
|---|---|
| Related Catalog | |
| In Vivo | pVXc-486 (oral gavage; 10, 30, 100 mg/kg; once per day; 5 times per week for 4 weeks) reduces the mycobacterial burden in a model of chronic tuberculosis infection in mice[1]. pVXc-486 (oral; 100 mg/kg; once per day; 5 days per week, for 8 weeks) improves the bactericidal activities of antimycobacterial drugs[1]. Animal Model: Six-week old female BALB/c and C57BL/6 mice uninfected or M. tuberculosis-infected (Erdman)[1] Dosage: 10, 30, 100 mg/kg Administration: Oral gavage; 5 times per week for 4 weeks Result: Reduced the mycobacterial burden in a model of chronic tuberculosis infection in mice. |
| References |
| Molecular Formula | C21H24FN6Na2O6P |
|---|---|
| Molecular Weight | 552.40 |
| InChIKey | BSOLRSNBVIVVMJ-FMOMHUKBSA-L |
| SMILES | CCNC(=O)Nc1nc2c(C3CCCO3)c(F)c(-c3cnc(C(C)(C)OP(=O)([O-])[O-])nc3)cc2[nH]1.[Na+].[Na+] |