rac-CCT 250863
Modify Date: 2024-01-12 14:49:45
rac-CCT 250863 structure
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Common Name | rac-CCT 250863 | ||
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| CAS Number | 1364269-06-6 | Molecular Weight | 490.541 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 582.9±50.0 °C at 760 mmHg | |
| Molecular Formula | C24H25F3N4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 306.3±30.1 °C | |
Use of rac-CCT 250863(Rac)-CCT 250863 (compound rac-21) is a selective and reversible NEK 2 inhibitor with an IC50 of 0.073 µM. (Rac)-CCT 250863 shows good effects of inducing cell cycle arrest and also can antiproliferative in cells (Pomalidomide sensitive/resistant). (Rac)-CCT 250863 induces apoptosis when combines with Pomalidomide[1][2]. |
| Name | 4-(2-Amino-5-{4-[(dimethylamino)methyl]-2-thienyl}-3-pyridinyl)-2-{[(3Z)-5,5,5-trifluoro-3-penten-2-yl]oxy}benzamide |
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| Synonym | More Synonyms |
| Description | (Rac)-CCT 250863 (compound rac-21) is a selective and reversible NEK 2 inhibitor with an IC50 of 0.073 µM. (Rac)-CCT 250863 shows good effects of inducing cell cycle arrest and also can antiproliferative in cells (Pomalidomide sensitive/resistant). (Rac)-CCT 250863 induces apoptosis when combines with Pomalidomide[1][2]. |
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| Related Catalog | |
| Target |
IC50: 0.073 µM (NEK 2), 8.0 μΜ (H929), 7.1 μΜ (AMOl), 8.7 μΜ (K12PE)[1][2]. |
| References |
[2]. Ahsan A, et al. Methods for treating cancer with combination therapies. WO2021262962A1. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 582.9±50.0 °C at 760 mmHg |
| Molecular Formula | C24H25F3N4O2S |
| Molecular Weight | 490.541 |
| Flash Point | 306.3±30.1 °C |
| Exact Mass | 490.165039 |
| LogP | 4.42 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.591 |
| MFCD30474714 |
| 4-(2-Amino-5-{4-[(dimethylamino)methyl]-2-thienyl}-3-pyridinyl)-2-{[(3Z)-5,5,5-trifluoro-3-penten-2-yl]oxy}benzamide |
| Benzamide, 4-[2-amino-5-[4-[(dimethylamino)methyl]-2-thienyl]-3-pyridinyl]-2-[[(2Z)-4,4,4-trifluoro-1-methyl-2-buten-1-yl]oxy]- |