GSK837149A
Modify Date: 2024-01-11 00:28:08
GSK837149A structure
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Common Name | GSK837149A | ||
|---|---|---|---|---|
| CAS Number | 13616-29-0 | Molecular Weight | 554.60100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H22N8O5S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of GSK837149AGSK837149A is a selective inhibitor of human Fatty Acid Synthase (FASN) targeting the KR domain. GSK837149A has reversible inhibition effect on FASN and selectivity for type I FASN (Ki=30 nM). GSK837149A is also a competitive inhibitor of NADPH and a non-competitive inhibitor of acetoacetyl-CoA. GSK837149A can be used for the research of obesity and breast cancer[1][2]. |
| Name | N,N'-bis-(4-methyl-pyrimidin-2-yl)-4,4'-carbonyldiamino-bis-benzenesulfonamide |
|---|---|
| Synonym | More Synonyms |
| Description | GSK837149A is a selective inhibitor of human Fatty Acid Synthase (FASN) targeting the KR domain. GSK837149A has reversible inhibition effect on FASN and selectivity for type I FASN (Ki=30 nM). GSK837149A is also a competitive inhibitor of NADPH and a non-competitive inhibitor of acetoacetyl-CoA. GSK837149A can be used for the research of obesity and breast cancer[1][2]. |
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| Related Catalog | |
| Target |
Ki: 30 nM (type I FASN)[1] |
| In Vitro | GSK837149A (0.1 nM-0.1 mM) 对乙酰辅酶 A/丙二酰辅酶 A 和乙酰乙酰辅酶 A 的抑制作用随作用浓度增加而增强[1]。 |
| References |
| Molecular Formula | C23H22N8O5S2 |
|---|---|
| Molecular Weight | 554.60100 |
| Exact Mass | 554.11500 |
| PSA | 201.79000 |
| LogP | 5.58260 |
| InChIKey | RSINKZJTTORDAJ-UHFFFAOYSA-N |
| SMILES | Cc1ccnc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccc(S(=O)(=O)Nc4nccc(C)n4)cc3)cc2)n1 |
| Storage condition | 2-8°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| N,N'-Di[4-(4-Methyl-pyrimidin-2-ylsulfamoyl)phenyl]-urea |