Amphotericin X1
Modify Date: 2025-08-27 11:57:03
Amphotericin X1 structure
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Common Name | Amphotericin X1 | ||
|---|---|---|---|---|
| CAS Number | 136135-57-4 | Molecular Weight | 938.11 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C48H75NO17 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Amphotericin X1Amphotericin X1 is an 13-O-methyl derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, C.parapsilosis 937A, Cryptococcus neoformans 451, Aspergillus niger 57A and A.fumigatus with MIC values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL and 2 μg/mL, respectively[1]. |
| Name | Amphotericin X1 |
|---|
| Description | Amphotericin X1 is an 13-O-methyl derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, C.parapsilosis 937A, Cryptococcus neoformans 451, Aspergillus niger 57A and A.fumigatus with MIC values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL and 2 μg/mL, respectively[1]. |
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| Related Catalog | |
| Target |
MIC: 1 μg/mL (Candida albicans 33/079), 8 μg/mL (C.parapsilosis 937A), 1 μg/mL (Cryptococcus neoformans 451), 2 μg/mL (Aspergillus niger 57A) and 2 μg/mL (A.fumigatus)[1] |
| In Vitro | Amphotericin X1 (compound 4) shows interesting antifungal activity combined with a pronounced reduction in haemolytic activity (EH50 of 42 μg/mL) against mammalianerythrocytes in vitro[1]. |
| References |
| Molecular Formula | C48H75NO17 |
|---|---|
| Molecular Weight | 938.11 |
| InChIKey | IJLVDQCUUOUTLI-ULTJZYGOSA-N |
| SMILES | COC12CC(O)CC(O)C(O)CCC(O)CC(O)CC(=O)OC(C)C(C)C(O)C(C)C=CC=CC=CC=CC=CC=CC=CC(OC3OC(C)C(O)C(N)C3O)CC(O1)C(C(=O)O)C(O)C2 |