Angiotensin III, human, mouse(Acetate)

Modify Date: 2025-08-25 18:22:49

Angiotensin III, human, mouse(Acetate) Structure
Angiotensin III, human, mouse(Acetate) structure
Common Name Angiotensin III, human, mouse(Acetate)
CAS Number 13602-53-4 Molecular Weight 931.09100
Density 1.39g/cm3 Boiling Point N/A
Molecular Formula C46H66N12O9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Angiotensin III, human, mouse(Acetate)


Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively.

 Names

Name angiotensin iii, human
Synonym More Synonyms

 Angiotensin III, human, mouse(Acetate) Biological Activity

Description Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively.
Related Catalog
Target

IC50: 0.648 nM (AT2R), 21.1 nM (AT1R)[1]

In Vitro Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively[1].
In Vivo Angiotensin III (7, 14 and 28 nmol/kg/min) increases urine sodium excretion (UNaV), fractional excretion of sodium (FENa), and fractional excretion of lithium (FELi) in SD rat[2]. In RAS (renin-angiotensin system), Angiotensin III increases sympathetic nerve activity and vasopressin release and decreases the baroreflex leading to higher blood pressure in rats[3].
References

[1]. Bosnyak S, et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin Sci (Lond). 2011 Oct;121(7):297-303.

[2]. Kemp BA, et al. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension. 2012 Aug;60(2):387-95.

[3]. Gao J, et al. A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors. Clin Sci (Lond). 2014 Aug;127(3):135-48.

 Chemical & Physical Properties

Density 1.39g/cm3
Molecular Formula C46H66N12O9
Molecular Weight 931.09100
Exact Mass 930.50800
PSA 339.94000
LogP 3.71910
Index of Refraction 1.657
Storage condition −20°C
Water Solubility H2O: 1.0 mg/mL, clear, colorless

 Safety Information

WGK Germany 3

 Synonyms

angiotensin I-converting enzyme
ACE INACTIVATOR
ANGIOTENSIN I-CONVERTING ENZYME INACTIVATOR
human AngIII
angiotensin III
CYANOAC-PHE-PHE-OH
H-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
CYANOAC-PHE-PHE
Angiotensin III, human, mouse
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