Perindopril-d4

Modify Date: 2024-01-29 19:16:26

Perindopril-d4 Structure
Perindopril-d4 structure
Common Name Perindopril-d4
CAS Number 1356929-58-2 Molecular Weight 372.49
Density 1.1±0.1 g/cm3 Boiling Point 537.4±45.0 °C at 760 mmHg
Molecular Formula C19H28D4N2O5 Melting Point N/A
MSDS N/A Flash Point 278.8±28.7 °C

 Names

Name (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-Ethoxy-1-oxo-2-pentanyl]amino}(2H4)propanoyl]octahydro-1H-indole-2-carboxylic acid (non-preferred name)

 Perindopril-d4 Biological Activity

Description Perindopril-d4 是 Perindopril氘代物[1]。
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 537.4±45.0 °C at 760 mmHg
Molecular Formula C19H28D4N2O5
Molecular Weight 372.49
Flash Point 278.8±28.7 °C
Exact Mass 372.256226
LogP 3.36
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.512