YLC2-155
Modify Date: 2024-10-01 18:35:17
YLC2-155 structure
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Common Name | YLC2-155 | ||
|---|---|---|---|---|
| CAS Number | 1354742-60-1 | Molecular Weight | 243.22 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H9NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of YLC2-155YLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT; binds at the RNase H (RNH)-active site in multiple conformations; demonstrates inhibition of fully infectious HIV-1 (strain NL4-3) with EC50 of 6.7 uM in cell-based assays. |
| Name | YLC2-155 |
|---|
| Description | YLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT; binds at the RNase H (RNH)-active site in multiple conformations; demonstrates inhibition of fully infectious HIV-1 (strain NL4-3) with EC50 of 6.7 uM in cell-based assays. |
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| References | References 1. Kirby KA, et al. Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01351-17. 2. Kirby KA, et al. Antimicrob Agents Chemother. 2012 Apr;56(4):2048-61. View Related Products by Target HIV |
| Molecular Formula | C13H9NO4 |
|---|---|
| Molecular Weight | 243.22 |
| InChIKey | FMBJYDTZYGCAIN-UHFFFAOYSA-N |
| SMILES | O=C1Cc2ccc(-c3ccco3)cc2C(=O)N1O |