NP-12
Modify Date: 2025-08-24 19:04:00
NP-12 structure
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Common Name | NP-12 | ||
|---|---|---|---|---|
| CAS Number | 1353564-66-5 | Molecular Weight | 3262.00 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C142H225N39O49 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NP-12NP-12 is a peptide antagonist of the PD-1 signaling pathway, which acts as an immunomodulatory agent for cancer therapy[1]. |
| Name | NP-12 |
|---|
| Description | NP-12 is a peptide antagonist of the PD-1 signaling pathway, which acts as an immunomodulatory agent for cancer therapy[1]. |
|---|---|
| Related Catalog | |
| Target |
PD-1[1] |
| In Vitro | NP-12 displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions [1]. NP-12 rescues the proliferation in the mouse splenocyte assay system, with average EC50 values of 17 nM and 16.6 nM against rmPD-L1 and rmPD-L2 respectively[1]. NP-12 is also able to significantly rescue recombinant human PD-L1 and PD-L2 mediated inhibition of in vitro human PBMC proliferation, with average EC50 values of 63.3 nM and 44.1 nM against PD-L1 and PD-L2 respectively[1]. |
| References |
| Molecular Formula | C142H225N39O49 |
|---|---|
| Molecular Weight | 3262.00 |