GS-5759
Modify Date: 2025-08-20 15:46:42
GS-5759 structure
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Common Name | GS-5759 | ||
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| CAS Number | 1346653-91-5 | Molecular Weight | 850.95 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C47H42N6O8S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GS-5759A novel bifunctional PDE4 inhibitor (IC50=5 nM) and long acting β2-adrenoceptor agonist (EC50=8 nM); inhibits LPS-induced TNFα production in human PBMC (IC50=0.3 nM) and in human neutrophils fMLP-induced super oxide anion production (IC50=3 nM); also is a potent inhibitor of profibrotic and proinflammatory mediator release from human lung fibroblasts. |
| Name | GS-5759 |
|---|
| Description | A novel bifunctional PDE4 inhibitor (IC50=5 nM) and long acting β2-adrenoceptor agonist (EC50=8 nM); inhibits LPS-induced TNFα production in human PBMC (IC50=0.3 nM) and in human neutrophils fMLP-induced super oxide anion production (IC50=3 nM); also is a potent inhibitor of profibrotic and proinflammatory mediator release from human lung fibroblasts. |
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| References | References 1. Tannheimer SL, et al. J Pharmacol Exp Ther. 2014 Apr;349(1):85-93. 2. Joshi T, et al. J Pharmacol Exp Ther. 2017 Feb;360(2):324-340. View Related Products by Target Phosphodiesterase (PDE) |
| Molecular Formula | C47H42N6O8S |
|---|---|
| Molecular Weight | 850.95 |
| InChIKey | HJBZAZITZDSWKD-VQJSHJPSSA-N |
| SMILES | COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)Nc5ccc(C#CCCCNCC(O)c6ccc(O)c7[nH]c(=O)ccc67)cc5)c4)cc23)c1 |