Akt1&PKA-IN-2

Modify Date: 2025-08-31 18:43:53

Akt1&PKA-IN-2 structure	Common Name	Akt1&PKA-IN-2
	CAS Number	1334108-00-7	Molecular Weight	386.27
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₇Cl₂N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Akt1&PKA-IN-2

Akt1&PKA-IN-2 ((R)-29) is an inhibitor of PKB/AKT with cyclin-dependent kinase 2 (CDK2) selectivity. Akt1&PKA-IN-2 inhibits AKT1, PKAa and CDK2a with IC50 values of 0.007 µM, 0.01 µM and 0.69 µM, respectively[1].

Name	Akt1&PKA-IN-2

Description	Akt1&PKA-IN-2 ((R)-29) is an inhibitor of PKB/AKT with cyclin-dependent kinase 2 (CDK2) selectivity. Akt1&PKA-IN-2 inhibits AKT1, PKAa and CDK2a with IC50 values of 0.007 µM, 0.01 µM and 0.69 µM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	Akt1:0.007 μM (IC50) CDK2a:0.69 μM (IC50)
References	[1]. Ashton KS, et al. Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5191-6.

Molecular Formula	C₂₀H₁₇Cl₂N₃O
Molecular Weight	386.27

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