β-Aminoarteether
Modify Date: 2025-08-25 17:46:14
β-Aminoarteether structure
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Common Name | β-Aminoarteether | ||
|---|---|---|---|---|
| CAS Number | 133162-24-0 | Molecular Weight | 327.42 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H29NO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of β-Aminoarteetherβ-Aminoarteether (SM934 free base) is an Artemisinin derivative with orally active. β-Aminoarteether can be used for inflammation and autoimmune disease research, such as lupus diseases[1]. |
| Name | β-Aminoarteether |
|---|
| Description | β-Aminoarteether (SM934 free base) is an Artemisinin derivative with orally active. β-Aminoarteether can be used for inflammation and autoimmune disease research, such as lupus diseases[1]. |
|---|---|
| Related Catalog | |
| In Vitro | β-Aminoarteether (SM934;10 µM; 24 hours) treatment directly enhances IL-10 production and suppresses IL-12/23p40 production in primary peritoneal macrophages with IFN-γ stimulation[1]. In vitro, β-Aminoarteether (SM934) could suppress the Th1 and Th17 polarization, but exerted no influence on Treg differentiation[1]. |
| In Vivo | β-Aminoarteether (SM934; 1-10 mg/kg; oral administration; daliy; for 3 months) treatment significantly delays the progression of glomerulonephritis and increases the survival rate of NZB/W F1 mice. β-Aminoarteether treatment promots the IL-10 production of macrophages from NZB/W F1 mice[1]. Animal Model: Female NZB/W F1 mice (Six and half months old)[1] Dosage: 1 mg/kg, 3 mg/kg, and 10 mg/kg Administration: Oral administration; daliy; for 3 months Result: Significantly delayed the progression of glomerulonephritis and increased the survival rate of NZB/W F1 mice. |
| References |
| Molecular Formula | C17H29NO5 |
|---|---|
| Molecular Weight | 327.42 |
| InChIKey | HPGHCIXRRLNXRN-XQLAAWPRSA-N |
| SMILES | CC1CCC2C(C)C(OCCN)OC3OC4(C)CCC1C32OO4 |