Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)

Modify Date: 2024-07-21 18:27:42

Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) structure	Common Name	Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
	CAS Number	131791-98-5	Molecular Weight	1427.48000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆₄H₈₆N₁₀O₂₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)

Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a KD < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM[1].

Name	Suc-Phe-Glu-Pro-Ile-Pro-Glu-Glu-Tyr(OSO3H)-Leu-D-Glu-OH
Synonym	More Synonyms

Description	Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a KD < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin
References	[1]. Dekker RJ, et al. The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop. J Mol Biol. 1999 Oct 29;293(3):613-27. [2]. Payne MH, et al. Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptides. J Med Chem. 1991 Mar;34(3):1184-7.

Description

Related Catalog

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin

References

[1]. Dekker RJ, et al. The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop. J Mol Biol. 1999 Oct 29;293(3):613-27.

[2]. Payne MH, et al. Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptides. J Med Chem. 1991 Mar;34(3):1184-7.

Molecular Formula	C₆₄H₈₆N₁₀O₂₅S
Molecular Weight	1427.48000
Exact Mass	1426.55000
PSA	540.18000
LogP	2.81340
InChIKey	YGKXPBZTQOZMGW-FQSUHZHRSA-N
SMILES	CCC(C)C(NC(=O)C1CCCN1C(=O)C(CCC(=O)O)NC(=O)C(Cc1ccccc1)N1C(=O)CCC1=O)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1ccc(OS(=O)(=O)O)cc1)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)O

Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Nanjing Peptide Biotech Ltd
China
Product Name: SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OH
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Delivery: 7 Day
Contact: jom
Email: chenglong.fan@njpeptide.com

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Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.