Acid-PEG5-mono-methyl ester

Modify Date: 2024-02-04 15:52:58

Acid-PEG5-mono-methyl ester Structure
Acid-PEG5-mono-methyl ester structure
Common Name Acid-PEG5-mono-methyl ester
CAS Number 1309460-30-7 Molecular Weight 352.377
Density 1.2±0.1 g/cm3 Boiling Point 469.4±45.0 °C at 760 mmHg
Molecular Formula C15H28O9 Melting Point N/A
MSDS N/A Flash Point 161.3±22.2 °C

 Use of Acid-PEG5-mono-methyl ester


Acid-PEG5-mono-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Acid-PEG5-mono-methyl ester
Synonym More Synonyms

 Acid-PEG5-mono-methyl ester Biological Activity

Description Acid-PEG5-mono-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 469.4±45.0 °C at 760 mmHg
Molecular Formula C15H28O9
Molecular Weight 352.377
Flash Point 161.3±22.2 °C
Exact Mass 352.173340
LogP -1.44
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.459

 Synonyms

3-Oxo-2,6,9,12,15,18-hexaoxahenicosan-21-oic acid
MFCD18916990
4,7,10,13,16-Pentaoxanonadecane-1,19-dioic acid, monomethyl ester