SPRi 3
Modify Date: 2024-01-08 18:51:12
SPRi 3 structure
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Common Name | SPRi 3 | ||
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| CAS Number | 1292285-54-1 | Molecular Weight | 262.30 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H18N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SPRi 3SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels[1][2][3]. |
| Name | SPR inhibitor 3 |
|---|
| Description | SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels[1][2][3]. |
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| Related Catalog | |
| Target |
IC50: 74 nM (sepiapterin reductase)[1] |
| In Vitro | SPR inhibitor 3 (SPRi3) also significantly reduces SPR activity in mouse primary cultures of sensory neurons (IC50=0.45 μM) without affecting the activity of GTP cyclohydroxylase 1 enzyme (GCH1)[1]. |
| References |
| Molecular Formula | C14H18N2O3 |
|---|---|
| Molecular Weight | 262.30 |