pTH (1-34) (bovine) structure
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Common Name | pTH (1-34) (bovine) | ||
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CAS Number | 12583-68-5 | Molecular Weight | 4108.71 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C183H288N54O50S2 | Melting Point | N/A | |
MSDS | USA | Flash Point | N/A |
Use of pTH (1-34) (bovine)Parathyroid Hormone (1-34), bovine is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis[1]. |
Name | Parathyroid Hormone(1-34) Bovine |
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Synonym | More Synonyms |
Description | Parathyroid Hormone (1-34), bovine is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis[1]. |
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Related Catalog | |
In Vitro | Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) are added to the medium, it inhibits osteoblast proliferation in a dose-dependent manner. In another group, bPTH are added to the culture medium from day 1 to day 10, but not from days 11 to 20, a rebound of proliferation is observed in the PTH Day 1–10 group after bPTH withdrawal[1]. Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) induces diverse effects on the calcium and phosphorus content of culture medium. The calcium and phosphorus content of culture medium in the PTH-C 100 ng/mL group are higher than in teh control group[1]. Cell Proliferation Assay[1] Cell Line: MC3T3-E1 cells Concentration: 0.1-100 ng/mL Incubation Time: 2-20 days Result: Resulted a decrease of osteoblast proliferationin concentration-dependent manner. Resulted in a rebound of proliferation when PTH withdrawal. |
In Vivo | Parathyroid Hormone (1-34)(subcutaneous injection; 80 μg/kg; 5 days) increases serum osteocalcin concentrations without changing serum inorganic phosphate or calcium concentrations in either group of old animals. Serum 1,25-dihydroxyvitamin D concentrations are significantly higher in the PTH-treated senile female rats than the sex-matchedvehicle-treated controls[1]. |
References |
Molecular Formula | C183H288N54O50S2 |
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Molecular Weight | 4108.71 |
Storage condition | -20°C |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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RIDADR | NONH for all modes of transport |
Thyroid hormones enhance the biomechanical functionality of scaffold-free neocartilage.
Arthritis. Res. Ther. 17 , 28, (2015) The aim of this study was to investigate the effects of thyroid hormones tri-iodothyronine (T3), thyroxine (T4), and parathyroid hormone (PTH) from the parathyroid glands, known to regulate the develo... |
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Identification of a novel parathyroid hormone-responsive gene in human osteoblastic cells.
Bone 24(4) , 305-13, (1999) Parathyroid hormone (PTH) is a potent stimulator of osteoblastic cell function in vitro and bone resorption and formation in vivo; however, the details of the molecular mechanism(s) responsible for PT... |
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Functional properties of a synthetic chicken parathyroid hormone-related protein 1-36 fragment.
J. Bone Miner Res. 9(7) , 1041-6, (1994) The biologic activities of human parathyroid hormone-related protein [hPTHrP(1-34] and bovine PTH [bPTH(1-34)] are remarkably similar despite marked sequence divergence in their primary binding domain... |
MFCD00147847 |