SAK 3
Modify Date: 2025-08-27 02:54:20
SAK 3 structure
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Common Name | SAK 3 | ||
|---|---|---|---|---|
| CAS Number | 1256269-87-0 | Molecular Weight | 369.414 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 539.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C20H23N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 280.0±32.9 °C | |
Use of SAK 3SAK3 (T-VGCC enhancer SAK3) is a potent, orally acitve enhancer of T-type voltage-gated Ca2+ channel (T-VGCC), enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01-10 nM in neuro2A cells in vitro; significantly enhanced acetylcholine (ACh) release in the hippocampal CA1 region of naïve mice (0.5 mg/kg, p.o.); significantly enhanced hippocampal ACh levels in olfactory-bulbectomized (OBX) mice, rescuing impaired memory-related behaviors. |
| Name | SAK3 |
|---|---|
| Synonym | More Synonyms |
| Description | SAK3 (T-VGCC enhancer SAK3) is a potent, orally acitve enhancer of T-type voltage-gated Ca2+ channel (T-VGCC), enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01-10 nM in neuro2A cells in vitro; significantly enhanced acetylcholine (ACh) release in the hippocampal CA1 region of naïve mice (0.5 mg/kg, p.o.); significantly enhanced hippocampal ACh levels in olfactory-bulbectomized (OBX) mice, rescuing impaired memory-related behaviors. |
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| References | References 1. Yabuki Y, et al. Neuropharmacology. 2017 May 1;117:1-13. 2. Izumi H, et al. Neuroscience. 2018 May 1;377:87-97. 3. Husain N, et al. Pharmacology. 2018;101(5-6):309-321. 4. Wang S, et al. PLoS One. 2018 Dec 20;13(12):e0206986. View Related Products by Target Calcium Channel |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 539.3±60.0 °C at 760 mmHg |
| Molecular Formula | C20H23N3O4 |
| Molecular Weight | 369.414 |
| Flash Point | 280.0±32.9 °C |
| Exact Mass | 369.168854 |
| LogP | 2.66 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.664 |
| SAK3 |
| Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate |
| 8'-Methyl-2',4-dioxo-2-(1-piperidinyl)-spiro[2-cyclopentene-1,3'(2'H)-imidazo[1,2-a]pyridine]-3-carboxylic acid ethyl ester |
| Spiro[cyclopent-2-ene-1,3'(2'H)-imidazo[1,2-a]pyridine]-3-carboxylic acid, 8'-methyl-2',4-dioxo-2-(1-piperidinyl)-, ethyl ester |
| Ethyl 8'-methyl-2',4-dioxo-2-(1-piperidinyl)-2'H-spiro[cyclopent-2-ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate |