Naftifine-d3 (hydrochloride)

Modify Date: 2024-01-23 19:19:47

Naftifine-d3 (hydrochloride) structure	Common Name	Naftifine-d3 (hydrochloride)
	CAS Number	1246833-81-7	Molecular Weight	326.878
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₉D₃ClN	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Naftifine-d3 (hydrochloride)

Naftifine-d3 hydrochloride is the deuterium labeled Naftifine hydrochloride. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition[1].

Name	Naftifine-d3 (hydrochloride)
Synonym	More Synonyms

Description	Naftifine-d3 hydrochloride is the deuterium labeled Naftifine hydrochloride. Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Georgopoulos, A., et al., In vitro activity of naftifine, a new antifungal agent. Antimicrob Agents Chemother, 1981. 19(3): p. 386-9. [3]. Ryder, N.S., G. Seidl, and P.F. Troke, Effect of the antimycotic drug naftifine on growth of and sterol biosynthesis in Candida albicans. Antimicrob Agents Chemother, 1984. 25(4): p. 483-7. [4]. Parish, L.C., et al., A double-blind, randomized, vehicle-controlled study evaluating the efficacy and safety of naftifine 2% cream in tinea cruris. J Drugs Dermatol, 2011. 10(10): p. 1142-7. [5]. Gupta, A.K., J.E. Ryder, and E.A. Cooper, Naftifine: a review. J Cutan Med Surg, 2008. 12(2): p. 51-8.

Molecular Formula	C₂₁H₁₉D₃ClN
Molecular Weight	326.878
Exact Mass	326.162903

Naftifine-d3 (hydrochloride)

(2E)-N-(2H3)Methyl-N-(1-naphthylmethyl)-3-phenyl-2-propen-1-amine hydrochloride (1:1)

1-Naphthalenemethanamine, N-(methyl-d3)-N-[(2E)-3-phenyl-2-propen-1-yl]-, hydrochloride (1:1)

Naftifine-d3 (hydrochloride)

Use of Naftifine-d3 (hydrochloride)

Names

Naftifine-d3 (hydrochloride) Biological Activity

Chemical & Physical Properties

Synonyms