(-)-Dihydroguaiaretic acid

Modify Date: 2024-01-14 10:10:09

(-)-Dihydroguaiaretic acid structure	Common Name	(-)-Dihydroguaiaretic acid
	CAS Number	124649-78-1	Molecular Weight	330.418
	Density	1.1±0.1 g/cm3	Boiling Point	488.3±40.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₆O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	249.1±27.3 °C

Use of (-)-Dihydroguaiaretic acid

(-)-Dihydroguaiaretic acid is a Lipoxygenase inhibitor that has antioxidant activity. (-)-Dihydroguaiaretic acid inhibits the oxidation of unsaturated fatty acids and removes free radicals. (-)-Dihydroguaiaretic acid also has anticancer activity with an IC50 value of 7.49 μM (A549 cells)[1][2].

Name	G8DW2Y2JBT
Synonym	More Synonyms

Description	(-)-Dihydroguaiaretic acid is a Lipoxygenase inhibitor that has antioxidant activity. (-)-Dihydroguaiaretic acid inhibits the oxidation of unsaturated fatty acids and removes free radicals. (-)-Dihydroguaiaretic acid also has anticancer activity with an IC50 value of 7.49 μM (A549 cells)[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
References	[1]. Yamauchi S, et al. Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic acid, and 7,7'-oxodihydroguaiaretic acid. Biosci Biotechnol Biochem. 2008 Nov;72(11):2981-6. [2]. Davis R A, et al. Isolation, structure elucidation and cytotoxic evaluation of endiandrin B from the Australian rainforest plant Endiandra anthropophagorum[J]. Bioorganic & medicinal chemistry, 2009, 17(3): 1387-1392.

Description

Related Catalog

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

References

[1]. Yamauchi S, et al. Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic acid, and 7,7'-oxodihydroguaiaretic acid. Biosci Biotechnol Biochem. 2008 Nov;72(11):2981-6.

[2]. Davis R A, et al. Isolation, structure elucidation and cytotoxic evaluation of endiandrin B from the Australian rainforest plant Endiandra anthropophagorum[J]. Bioorganic & medicinal chemistry, 2009, 17(3): 1387-1392.

Density	1.1±0.1 g/cm3
Boiling Point	488.3±40.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₆O₄
Molecular Weight	330.418
Flash Point	249.1±27.3 °C
Exact Mass	330.183105
LogP	4.33
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.564

G8DW2Y2JBT

4,4'-[(2R,3R)-2,3-Dimethyl-1,4-butanediyl]bis(2-methoxyphenol)

Phenol, 4,4'-[(2R,3R)-2,3-dimethyl-1,4-butanediyl]bis[2-methoxy-

4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]bis(2-methoxyphenol)

(-)-dihydroguaiaretic acid

(-)-Dihydroguaiaretic acid

Use of (-)-Dihydroguaiaretic acid

Names

(-)-Dihydroguaiaretic acid Biological Activity

Chemical & Physical Properties

Synonyms