(Rac)-Tivantinib

Modify Date: 2024-01-03 14:18:51

(Rac)-Tivantinib Structure
(Rac)-Tivantinib structure
Common Name (Rac)-Tivantinib
CAS Number 1239986-50-5 Molecular Weight 369.42
Density 1.5±0.1 g/cm3 Boiling Point 716.0±60.0 °C at 760 mmHg
Molecular Formula C23H19N3O2 Melting Point N/A
MSDS N/A Flash Point 386.8±32.9 °C

 Use of (Rac)-Tivantinib


(Rac)-Tivantinib is the inactive isomer of Tivantinib (HY-50686), and can be used as an experimental control. Tivantinib is a highly selective c-Met tyrosine kinase inhibitor with a Ki of 355 nM.

 Names

Name 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione
Synonym More Synonyms

 (Rac)-Tivantinib Biological Activity

Description (Rac)-Tivantinib is the inactive isomer of Tivantinib (HY-50686), and can be used as an experimental control. Tivantinib is a highly selective c-Met tyrosine kinase inhibitor with a Ki of 355 nM.
Related Catalog
References

[1]. Bai YL, et al. Quantitative analysis of tivantinib in rat plasma using ultra performance liquid chromatography with tandem mass spectrometry. J Pharm Biomed Anal. 2016 Jul 15;126:98-102.  

[2]. Munshi N, et al. ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity. Mol Cancer Ther. 2010 Jun;9(6):1544-53.  

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 716.0±60.0 °C at 760 mmHg
Molecular Formula C23H19N3O2
Molecular Weight 369.42
Flash Point 386.8±32.9 °C
Exact Mass 369.147736
PSA 70.38000
LogP 3.26
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.797

 Safety Information

HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2,5-Pyrrolidinedione, 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-
3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-2,5-pyrrolidinedione
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