LSD1-IN-20

Modify Date: 2025-08-26 22:35:18

LSD1-IN-20 Structure
LSD1-IN-20 structure
 Common Name LSD1-IN-20
CAS Number 1239589-91-3 Molecular Weight 478.63
Density N/A Boiling Point N/A
Molecular Formula C27H38N6O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LSD1-IN-20


LSD1-IN-20 (compound 1) is a potent dual non-covalent LSD1/G9a inhibitor, with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.51 and 1.60 μM, respectively[1].

 Names

Name LSD1-IN-20

 LSD1-IN-20 Biological Activity

Description LSD1-IN-20 (compound 1) is a potent dual non-covalent LSD1/G9a inhibitor, with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.51 and 1.60 μM, respectively[1].
Related Catalog
Target

Ki of 0.440 ± 0.05 μM (LSD1), 0.68 ± 0.02 μM (G9a)[1]

References

[1]. Menna M, et al. Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur J Med Chem. 2022 Jul 5;237:114410.

 Chemical & Physical Properties

Molecular Formula C27H38N6O2
Molecular Weight 478.63
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