NAB-14
Modify Date: 2025-12-01 16:54:01
NAB-14 structure
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Common Name | NAB-14 | ||
|---|---|---|---|---|
| CAS Number | 1237541-73-9 | Molecular Weight | 351.406 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H21N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NAB-14NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors; inhibits triheteromeric (GluN1/GluN2A/GluN2C) NMDARs with modestly reduced potency and efficacy compared to diheteromeric (GluN1/GluN2C/GluN2C) receptors; inhibits GluN2D-mediated synaptic currents in rat subthalamic neurons and mouse hippocampal interneurons, but has no effect on synaptic transmission in hippocampal pyramidal neurons. |
| Name | NAB-14 |
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| Description | NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors; inhibits triheteromeric (GluN1/GluN2A/GluN2C) NMDARs with modestly reduced potency and efficacy compared to diheteromeric (GluN1/GluN2C/GluN2C) receptors; inhibits GluN2D-mediated synaptic currents in rat subthalamic neurons and mouse hippocampal interneurons, but has no effect on synaptic transmission in hippocampal pyramidal neurons. |
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| References | References 1. Swanger SA, et al. ACS Chem Neurosci. 2018 Feb 21;9(2):306-319. View Related Products by Target iGluR |
| Molecular Formula | C20H21N3O3 |
|---|---|
| Molecular Weight | 351.406 |
| InChIKey | WCGIKJOMEYPSIP-UHFFFAOYSA-N |
| SMILES | CCN(CC)C(=O)Oc1ccc(C(=O)Nc2cccc3cc[nH]c23)cc1 |