RSL3

Modify Date: 2025-08-26 16:50:13

Use of RSL3

RSL3 (1S,3R-) is a glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 10 μM in cellular assay.

Name	Methyl (1S,3R)-2-(chloroacetyl)-1-[4-(methoxycarbonyl)phenyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate
Synonym	More Synonyms

Description	RSL3 (1S,3R-) is a glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 10 μM in cellular assay.
Related Catalog	Research Areas >> Cancer
References	[1]. Christina Schott et al. Oncogenic RAS Mutants Confer Resistance of RMS13 Rhabdomyosarcoma Cells to Oxidative Stress-Induced Ferroptotic Cell Death.Front Oncol. 2015, 5: 131. [2]. Michel Weiwer et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorganic & Medicinal Chemistry Letters 22 (2012) 1822-1826. [3]. Wan Seok Yang et al. Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells. Chem Biol, 2008 Mar, 15(3): 234-245.

Description

RSL3 (1S,3R-) is a glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 10 μM in cellular assay.

Related Catalog

Research Areas >> Cancer

References

Density	1.4±0.1 g/cm3
Boiling Point	641.3±55.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₁ClN₂O₅
Molecular Weight	440.876
Flash Point	341.6±31.5 °C
Exact Mass	440.113892
LogP	3.07
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.636
InChIKey	TXJZRSRTYPUYRW-NQIIRXRSSA-N
SMILES	COC(=O)c1ccc(C2c3[nH]c4ccccc4c3CC(C(=O)OC)N2C(=O)CCl)cc1
Storage condition	2-8°C

1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-, methyl ester, (1S,3R)-

Methyl (1S,3R)-2-(chloroacetyl)-1-[4-(methoxycarbonyl)phenyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylate

RSL3

RSL3 (1S,3R-)

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Price: $175/10mM*1mLinDMSO

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