Loxoribine
Modify Date: 2024-01-04 16:54:26
Loxoribine structure
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Common Name | Loxoribine | ||
|---|---|---|---|---|
| CAS Number | 121288-39-9 | Molecular Weight | 339.30400 | |
| Density | 1.92g/cm3 | Boiling Point | 591.8ºC at 760mmHg | |
| Molecular Formula | C13H17N5O6 | Melting Point | 227-230ºC(lit.) | |
| MSDS | N/A | Flash Point | 311.7ºC | |
Use of LoxoribineLoxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist[1][2][3]. |
| Name | 7-allyl-8-oxoguanosine |
|---|---|
| Synonym | More Synonyms |
| Description | Loxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
TLR7[1] |
| In Vitro | Loxoribine induces maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability[2]. Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54 and CCR7[2]. loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway[1]. |
| In Vivo | Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells in vivo[3]. Animal Model: 8-12 weeks male CBA/J mice[3] Dosage: 2 mg Administration: Subcutaneous or intravenous injection Result: activates murine natural killer (NK) cells in vivo. |
| References |
| Density | 1.92g/cm3 |
|---|---|
| Boiling Point | 591.8ºC at 760mmHg |
| Melting Point | 227-230ºC(lit.) |
| Molecular Formula | C13H17N5O6 |
| Molecular Weight | 339.30400 |
| Flash Point | 311.7ºC |
| Exact Mass | 339.11800 |
| PSA | 168.62000 |
| Vapour Pressure | 1.81E-16mmHg at 25°C |
| Index of Refraction | 1.812 |
| Storage condition | Desiccate at +4°C |
| WGK Germany | 3 |
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~99%
Loxoribine CAS#:121288-39-9 |
| Literature: WO2013/67597 A1, ; Page/Page column 108 ; |
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Loxoribine CAS#:121288-39-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 37, # 21 p. 3561 - 3578 |
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Loxoribine CAS#:121288-39-9 |
| Literature: Nucleosides and Nucleotides, , vol. 13, # 1-3 p. 551 - 562 |
| 7-ALLYL-7 8-DIHYDRO-8-OXOGUANOSINE 95 |
| 7-allyl-8-oxo-G |
| Loxoribine |
| 7-Allyl-7,8-dihydro-8-oxoguanosine |
| MFCD00867591 |