Indophagolin
Modify Date: 2024-01-01 21:59:10
Indophagolin structure
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Common Name | Indophagolin | ||
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| CAS Number | 1207660-00-1 | Molecular Weight | 523.75 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H15BrClF3N2O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IndophagolinIndophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7[1]. |
| Name | Indophagolin |
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| Description | Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7[1]. |
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| Related Catalog | |
| In Vitro | Indophagolin (10 μM) inhibits autophagosome formation in MCF7 cells[1]. |
| References |
| Molecular Formula | C19H15BrClF3N2O3S |
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| Molecular Weight | 523.75 |
| Storage condition | 2-8°C |