EM 163
Modify Date: 2025-10-29 17:54:14
EM 163 structure
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Common Name | EM 163 | ||
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| CAS Number | 1206480-93-4 | Molecular Weight | 849.88 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C44H60IN5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EM 163EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR structural domain in the IL-1 receptor and blocks the interaction with MyD88. EM 163 inhibits the production of inflammatory cytokines in vivo caused by staphylococcal enterotoxin B (SEB). EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocked the activation of p38 and the inhibitory effect of IL-1β on chemically induced long-term potentiation (LTP)-triggered protein synthesis. |
| Name | EM 163 |
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| Description | EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR structural domain in the IL-1 receptor and blocks the interaction with MyD88. EM 163 inhibits the production of inflammatory cytokines in vivo caused by staphylococcal enterotoxin B (SEB). EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocked the activation of p38 and the inhibitory effect of IL-1β on chemically induced long-term potentiation (LTP)-triggered protein synthesis. |
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| In Vivo | Notably, a novel TIR domain peptidomimetic (EM163) blocked both the activation of p38 and the suppression of cLTP-dependent protein synthesis by IL-1β. Our data support a model where IL-1β suppresses LTP directly in neurons by inhibiting mTOR-dependent translation.[1] |
| References | 1. Prieto GA, et al. Inhibition of LTP-Induced Translation by IL-1β Reduces the Level of Newly Synthesized Proteins in Hippocampal Dendrites. ACS Chem Neurosci. 2019;10(3):1197-1203. |
| Molecular Formula | C44H60IN5O4 |
|---|---|
| Molecular Weight | 849.88 |
| InChIKey | WJCJDZIXEVJIKZ-OFUZFLEOSA-M |
| SMILES | CC(C)C(C(=O)N1CCCC1)N(CCCc1ccccc1)C(=O)c1ccc(C(=O)N(CCCc2ccccc2)C(C(=O)N2CCCC2)C(C)C)[n+](C)c1.[I-] |