CAY10621(SKI 5C)

Modify Date: 2025-08-25 16:37:29

CAY10621(SKI 5C) Structure
CAY10621(SKI 5C) structure
 Common Name CAY10621(SKI 5C)
CAS Number 120005-55-2 Molecular Weight 435.640
Density 1.0±0.1 g/cm3 Boiling Point 519.0±60.0 °C at 760 mmHg
Molecular Formula C26H45NO4 Melting Point N/A
MSDS Chinese USA Flash Point 267.7±32.9 °C

 Use of CAY10621(SKI 5C)


CAY10621 (SKI 5C; compound 5c) is a specific sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 3.3 μM. CAY10621 is low toxic toward cells. CAY10621 has the potential for resistant cancer tumors research[1].

 Names

Name (S)-tert-butyl 4-(hexadec-2-ynoyl)-2,2-dimethyloxazolidine-3-carboxylate
Synonym More Synonyms

 CAY10621(SKI 5C) Biological Activity

Description CAY10621 (SKI 5C; compound 5c) is a specific sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 3.3 μM. CAY10621 is low toxic toward cells. CAY10621 has the potential for resistant cancer tumors research[1].
Related Catalog
References

[1]. Lingkai Wong, et al. Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. J Med Chem. 2009 Jun 25;52(12):3618-26.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 519.0±60.0 °C at 760 mmHg
Molecular Formula C26H45NO4
Molecular Weight 435.640
Flash Point 267.7±32.9 °C
Exact Mass 435.334869
PSA 55.84000
LogP 8.67
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.478

 Safety Information

RIDADR NONH for all modes of transport

 Synthetic Route

1-Pentadecyne structure

1-Pentadecyne

CAS#:765-13-9

(S)-3-(TERT-BUTOXYCARBONYL)-2,2-DIMETHYLOXAZOLIDINE-4-CARBOXYLIC ACID structure

(S)-3-(TERT-BUT...

CAS#:139009-66-8

~61%

CAY10621(SKI 5C) Structure

CAY10621(SKI 5C)

CAS#:120005-55-2

Literature: Morales-Serna, Jose Antonio; Sauza, Alejandro; Padron De Jesus, Gabriela; Gavino, Ruben; Garcia De La Mora, Gustavo; Cardenas, Jorge Tetrahedron Letters, 2013 , vol. 54, # 52 p. 7111 - 7114
(4S,1'R)-4-(1'-Hydroxy-2'-hexadecinyl)-2,2-dimethyl-3-oxazolidincarbonsaeure-tert-butylester structure

(4S,1'R)-4-(1'-...

CAS#:115464-01-2

~82%

CAY10621(SKI 5C) Structure

CAY10621(SKI 5C)

CAS#:120005-55-2

Literature: Nimkar; Menaldino; Merrill; Liotta Tetrahedron Letters, 1988 , vol. 29, # 25 p. 3037 - 3040
4,8-dicyano-1,2,4,8-tetramethyl-3,9-dioxatricyclo-[5.2.1.02,6]decane structure

4,8-dicyano-1,2...

CAS#:785828-30-0

~82%

CAY10621(SKI 5C) Structure

CAY10621(SKI 5C)

CAS#:120005-55-2

Literature: Sawatzki, Peter; Kolter, Thomas European Journal of Organic Chemistry, 2004 , # 17 p. 3693 - 3700
(s)-(-)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyl-1,3-oxazolidine structure

(s)-(-)-3-tert-...

CAS#:102308-32-7

~%

CAY10621(SKI 5C) Structure

CAY10621(SKI 5C)

CAS#:120005-55-2

Literature: Nimkar; Menaldino; Merrill; Liotta Tetrahedron Letters, 1988 , vol. 29, # 25 p. 3037 - 3040
1-Pentadecyne structure

1-Pentadecyne

CAS#:765-13-9

~%

CAY10621(SKI 5C) Structure

CAY10621(SKI 5C)

CAS#:120005-55-2

Literature: Sawatzki, Peter; Kolter, Thomas European Journal of Organic Chemistry, 2004 , # 17 p. 3693 - 3700
Boc-Ser-OH structure

Boc-Ser-OH

CAS#:3262-72-4

~%

CAY10621(SKI 5C) Structure

CAY10621(SKI 5C)

CAS#:120005-55-2

Literature: Nimkar; Menaldino; Merrill; Liotta Tetrahedron Letters, 1988 , vol. 29, # 25 p. 3037 - 3040
BOC-ON structure

BOC-ON

CAS#:58632-95-4

~%

CAY10621(SKI 5C) Structure

CAY10621(SKI 5C)

CAS#:120005-55-2

Literature: Nimkar; Menaldino; Merrill; Liotta Tetrahedron Letters, 1988 , vol. 29, # 25 p. 3037 - 3040
Boc-Ser-OMe structure

Boc-Ser-OMe

CAS#:2766-43-0

~%

CAY10621(SKI 5C) Structure

CAY10621(SKI 5C)

CAS#:120005-55-2

Literature: Nimkar; Menaldino; Merrill; Liotta Tetrahedron Letters, 1988 , vol. 29, # 25 p. 3037 - 3040
(R)-3-tert-butyl 4-methyl 2,2-dimethyloxazolidine-3,4-dicarboxylate structure

(R)-3-tert-buty...

CAS#:95715-86-9

~%

CAY10621(SKI 5C) Structure

CAY10621(SKI 5C)

CAS#:120005-55-2

Literature: Nimkar; Menaldino; Merrill; Liotta Tetrahedron Letters, 1988 , vol. 29, # 25 p. 3037 - 3040

 Articles1

More Articles
Sphingosine kinase 1 promotes tumour cell migration and invasion via the S1P/EDG1 axis in hepatocellular carcinoma.

Liver Int. 32(2) , 331-8, (2012)

Sphingosine kinase 1 (SphK1), which phosphorylates sphingosine to sphingosine-1-phosphate (S1P), is overexpressed in various types of cancers, and may act as an oncogene in tumorigenesis. However, lit...

 Synonyms

2-Methyl-2-propanyl (4S)-4-(2-hexadecynoyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
3-Oxazolidinecarboxylic acid, 2,2-dimethyl-4-(1-oxo-2-hexadecyn-1-yl)-, 1,1-dimethylethyl ester, (4S)-
z-n-e-boc-l-lysine amide
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Chemsrc provides CAY10621(SKI 5C)(CAS#:120005-55-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of CAY10621(SKI 5C) are included as well.>> amp version: CAY10621(SKI 5C)

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