MV1035
Modify Date: 2024-07-20 14:15:51
MV1035 structure
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Common Name | MV1035 | ||
|---|---|---|---|---|
| CAS Number | 1199944-04-1 | Molecular Weight | 258.339 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H14N2Os | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MV1035MV1035 (MV-1035) is a novel small molecule that reduce U87 GBM cells migration and invasiveness, targeting m6A demethylase ALKBH5, also inhibits ALKBH2;MV1035 directly inhibits active recombinant ALKBH5 protein and, consequently, negatively regulates CD73 protein expression without affecting CD73 mRNA transcription.In PD-GSCs, MV1035 has a synergistic effect with TMZ in reducing cell viability and their ability to form spheres.MV1035 is able both to reduce the expression of MGMT and to inhibit ALKBH2 activity. |
| Name | MV1035 |
|---|
| Description | MV1035 (MV-1035) is a novel small molecule that reduce U87 GBM cells migration and invasiveness, targeting m6A demethylase ALKBH5, also inhibits ALKBH2;MV1035 directly inhibits active recombinant ALKBH5 protein and, consequently, negatively regulates CD73 protein expression without affecting CD73 mRNA transcription.In PD-GSCs, MV1035 has a synergistic effect with TMZ in reducing cell viability and their ability to form spheres.MV1035 is able both to reduce the expression of MGMT and to inhibit ALKBH2 activity. |
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| References | 1. Malacrida A, et al. Bioorg Med Chem. 2020 Feb 15;28(4):115300. 2. Malacrida A, et al. Biology (Basel). 2022 Jan 4;11(1):70. |
| Molecular Formula | C14H14N2Os |
|---|---|
| Molecular Weight | 258.339 |