CDFI

Use of CDFI

CDFI is an inhibitor of the lipid II flippase MurJ. CDFI potentiates the activity of β-lactams against MRSA[1][2].

Name	CDFI

Description	CDFI is an inhibitor of the lipid II flippase MurJ. CDFI potentiates the activity of β-lactams against MRSA[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
References	[1]. Fernandes PB, et al. Revisiting the Role of VraTSR in Staphylococcus aureus Response to Cell Wall-Targeting Antibiotics. J Bacteriol. 2022 Aug 16;204(8):e0016222. [2]. Dhanda G, et al. Antibiotic Adjuvants: A Versatile Approach to Combat Antibiotic Resistance. ACS Omega. 2023 Mar 14;8(12):10757-10783.

Description

CDFI is an inhibitor of the lipid II flippase MurJ. CDFI potentiates the activity of β-lactams against MRSA[1][2].

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Others >> Others

References

Molecular Formula	C₂₈H₂₈ClFN₂
Molecular Weight	446.99
InChIKey	KRLGPLURVLJNOH-UHFFFAOYSA-N
SMILES	Cc1cccc(CN2CCC(c3c(-c4ccccc4Cl)[nH]c4ccc(F)cc34)CC2)c1C