Esomeprazole
Modify Date: 2024-01-02 16:14:11
Esomeprazole structure
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Common Name | Esomeprazole | ||
|---|---|---|---|---|
| CAS Number | 119141-88-7 | Molecular Weight | 345.416 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 600.0±60.0 °C at 760 mmHg | |
| Molecular Formula | C17H19N3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 316.7±32.9 °C | |
Use of EsomeprazoleEsomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3]. |
| Name | esomeprazole |
|---|---|
| Synonym | More Synonyms |
| Description | Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
H+, K+-ATPase[1][2] |
| In Vitro | Esomeprazole (25-100 µM; 20 hours; MDA-MB-468 cells) treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification[1]. Cell Viability Assay[1] Cell Line: MDA-MB-468 cells Concentration: 25 µM, 50 µM, 75 µM, 100 µM Incubation Time: 20 hours Result: Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner. |
| In Vivo | Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis[2]. Animal Model: C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury[2] Dosage: 30 mg/kg, 300 mg/kg Administration: Oral gavage; daily; for 19 or 11 days Result: Significantly inhibited the progression of fibrosis throughout the lungs of the animals. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 600.0±60.0 °C at 760 mmHg |
| Molecular Formula | C17H19N3O3S |
| Molecular Weight | 345.416 |
| Flash Point | 316.7±32.9 °C |
| Exact Mass | 345.114716 |
| PSA | 96.31000 |
| LogP | 2.17 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.669 |
| Hazard Codes | Xn |
|---|---|
| HS Code | 2933990090 |
|
~92%
Esomeprazole CAS#:119141-88-7 |
| Literature: Che, Guoyong; Xiang, Jing; Tian, Tian; Huang, Qingfei; Cun, Linfeng; Liao, Jian; Wang, Qiwei; Zhu, Jin; Deng, Jingen Tetrahedron Asymmetry, 2012 , vol. 23, # 6-7 p. 457 - 460 |
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Esomeprazole CAS#:119141-88-7 |
| Literature: WO2007/88559 A1, ; Page/Page column 9-10 ; |
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Esomeprazole CAS#:119141-88-7 |
| Literature: US2011/213155 A1, ; Page/Page column 2 ; |
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~72%
Esomeprazole CAS#:119141-88-7 |
| Literature: Reddy, Lekkala Amarnath; Malakondaiah, Golla China; Babu, Karrothu Srihari; Bhattacharya, Apurba; Bandichhor, Rakeshwar; Himabindu, Vimmidi; Reddy, Padi Pratap; Anand, Ramasamy Vijaya Organic Process Research and Development, 2008 , vol. 12, # 1 p. 66 - 68 |
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~%
Esomeprazole CAS#:119141-88-7 |
| Literature: US2005/267157 A1, ; Page/Page column 10-11 ; |
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Esomeprazole CAS#:119141-88-7 |
| Literature: EP1992619 A1, ; Page/Page column 17 ; |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| S-enantiomer of omeprazole |
| Nexium |
| esomeprazolum |
| (-)-Omeprazole |
| (S)-(-)-Omeprazole |
| 1H-Benzimidazole, 5-methoxy-2-[(S)-[(1S)-(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]- |
| Esomeprazole (INN) |
| perprazole |
| (S)-Omeprazole |
| MFCD06798050 |
| EINECS 201-212-8 |
| 6-Methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole |
| [14C]-(-)-Omeprazole |
| 1H-Benzimidazole, 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]- |
| (S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole |
| (S)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole |
| Esomeprazole |
| 5-Methoxy-2-{(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl}-1H-benzimidazole |
| esomeprazol |
| (S)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole |
| (S)-Esomeprazole |
| UNII-N3PA6559FT |
| 6-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole |
| 5-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole |
- DC Chemicals Limited
- China
- Product Name: Esomeprazole
- Price: $200.0/100mg $400.0/250mg $800.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Esomeprazole
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Esomeprazole
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: Esomeprazole
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
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