MK-2 Inhibitor III
Modify Date: 2025-10-12 18:14:55
MK-2 Inhibitor III structure
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Common Name | MK-2 Inhibitor III | ||
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| CAS Number | 1186648-22-5 | Molecular Weight | 358.393 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H18N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MK-2 Inhibitor IIIMK-2 Inhibitor III (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 0.85 nM, and is exceptional selectivity against MK-3 (IC50=0.21 μM), MK-5 (IC50=0.081 μM), ERK2 (IC50=3.44 μM), MNK1(IC50=5.7 μM) as well as CDK2, JNK2, IKK2, MSK1, and MSK2[1]. |
| Name | 2-[2-(3-Quinolinyl)-4-pyridinyl]-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one hydrate (1:1) |
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| Synonym | More Synonyms |
| Description | MK-2 Inhibitor III (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 0.85 nM, and is exceptional selectivity against MK-3 (IC50=0.21 μM), MK-5 (IC50=0.081 μM), ERK2 (IC50=3.44 μM), MNK1(IC50=5.7 μM) as well as CDK2, JNK2, IKK2, MSK1, and MSK2[1]. |
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| Related Catalog | |
| Target |
IC50: 0.85 nM (MK-2), 0.21 μM (MK-3), 0.081 μM (MK-5), 3.44 μM (ERK2), 5.7 μM (MNK1)[1] |
| In Vitro | MK-2 Inhibitor III suppresses TNFα production in U397 cells with an IC50 of 4.4 μM[1]. |
| References |
| Molecular Formula | C21H18N4O2 |
|---|---|
| Molecular Weight | 358.393 |
| Exact Mass | 358.142975 |
| InChIKey | NIKCVKMHGQQSRN-UHFFFAOYSA-N |
| SMILES | O.O=C1NCCc2[nH]c(-c3ccnc(-c4cnc5ccccc5c4)c3)cc21 |
| Hazard Codes | Xi |
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| 2-[2-(3-Quinolinyl)-4-pyridinyl]-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one hydrate (1:1) |
| 4H-Pyrrolo[3,2-c]pyridin-4-one, 1,5,6,7-tetrahydro-2-[2-(3-quinolinyl)-4-pyridinyl]-, hydrate (1:1) |