ALW-II-41-27
Modify Date: 2025-08-25 10:55:42
ALW-II-41-27 structure
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Common Name | ALW-II-41-27 | ||
|---|---|---|---|---|
| CAS Number | 1186206-79-0 | Molecular Weight | 607.68900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H32F3N5O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ALW-II-41-27ALW-II-41-27 is a Eph family tyrosine kinase inhibitor with an IC50 of 11 nM for Eph2. |
| Name | N-[5-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]carbamoyl]-2-methylphenyl]-5-thiophen-2-ylpyridine-3-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | ALW-II-41-27 is a Eph family tyrosine kinase inhibitor with an IC50 of 11 nM for Eph2. |
|---|---|
| Related Catalog | |
| Target |
IC50: 11 nM (Eph2)[1] |
| In Vitro | ALW-II-41-27 inhibits Ba/F3 cells transformed with Tel fusions of EphA3, Kit, Fms, KDR, FLT1, FGR, Src, Lyn, Bmx, and Bcr-Abl with an EC50 below 500 nM. ALW-II-41-27 exhibits cross reactivity with Bcr-Abl. ALW-II-41-27 inhibits b-raf, CSF1R, DDR1, DDR2, EphA2, EphA5, EphA8, EphB1, EphB2, EphB3, Frk, Kit, Lck, p38α, p38β, PDGFRα, PDGFRβ, and Raf1 and many more demonstrating how introduction of the thiophene group can have a tremendous impact on kinase selectivity[1]. |
| References |
| Molecular Formula | C32H32F3N5O2S |
|---|---|
| Molecular Weight | 607.68900 |
| Exact Mass | 607.22300 |
| PSA | 112.79000 |
| LogP | 7.42320 |
| Storage condition | 2-8℃ |
![3-amino-N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)p henyl]-4-methyl-benzamide structure](https://image.chemsrc.com/caspic/241/872332-67-7.png)
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| hms2043h01 |
| hms2218g07 |
| cs-1203 |
| alw-ii-41-27 |