MK-8353;SCH900353
Modify Date: 2025-08-25 20:09:12
MK-8353;SCH900353 structure
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Common Name | MK-8353;SCH900353 | ||
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| CAS Number | 1184173-73-6 | Molecular Weight | 691.84 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C37H41N9O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MK-8353;SCH900353MK-8353 is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity. |
| Name | MK-8353 |
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| Description | MK-8353 is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity. |
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| Related Catalog | |
| Target |
ERK2:8.8 nM (IC50) ERK1:23 nM (IC50) |
| In Vitro | MK-8353 is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity. MK-8353 only at 1 μM shows >50% inhibition on 3 kinases (CLK2, FLT4, and Aurora B), and no other kinases tested are inhibited by >35% at 0.1 μM. MK-8353 also shows potent antitumor activity against various cancer cell lines, such Malme-3M cells (Melanoma), Colo-205 cells (Colon), NCI-H292 cells (Lung), A-549 cells (NSCLC), 8505C cells (Thyroid), SW-626 cells (Ovarian), with EC50s of 21 nM, 19 nM, 130 nM, 230 nM, 210 nM, 108 nM[1]. |
| In Vivo | MK-8353 (60 mg/kg, p.o., bid (twice daily)) causes at least 50% tumor growth inhibition or regression in 83% of the animal models bearing different tumor cells, including LOX, Colo-205, MIA PaCa-2, and Calu-6 cells[1]. |
| References |
| Molecular Formula | C37H41N9O3S |
|---|---|
| Molecular Weight | 691.84 |
| Storage condition | -20℃ |