MT47-100
Modify Date: 2024-07-19 13:24:02
MT47-100 structure
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Common Name | MT47-100 | ||
|---|---|---|---|---|
| CAS Number | 1179347-23-9 | Molecular Weight | 354.358 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 697.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C22H14N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 375.5±31.5 °C | |
Use of MT47-100A novel potent, allosteric, simultaneously direct activator and inhibitor of AMPK complexes containing the β1 or β2 isoform, respectively; maximally activates α1β1γ1 approximately 2.5-fold with half-maximal activation Ka of 3.7 uM and activates all AMPKβ1 complexes regardless α or γ isoforms; directly inhibits AMPKβ2 complexes independently of α or γ isoforms with Ki of 24.8 uM, this inhibition is dependent on the β2 carbohydrate-binding module (CBM) and independent of β2-Ser108 phosphorylation; augmentes glucose-stimulated insulin secretion from isolated mouse pancreatic islets via a β2-dependent mechanism. |
| Name | 2,4-Dihydroxy-6-(2'-hydroxy-4-biphenylyl)-3-quinolinecarbonitrile |
|---|---|
| Synonym | More Synonyms |
| Description | A novel potent, allosteric, simultaneously direct activator and inhibitor of AMPK complexes containing the β1 or β2 isoform, respectively; maximally activates α1β1γ1 approximately 2.5-fold with half-maximal activation Ka of 3.7 uM and activates all AMPKβ1 complexes regardless α or γ isoforms; directly inhibits AMPKβ2 complexes independently of α or γ isoforms with Ki of 24.8 uM, this inhibition is dependent on the β2 carbohydrate-binding module (CBM) and independent of β2-Ser108 phosphorylation; augmentes glucose-stimulated insulin secretion from isolated mouse pancreatic islets via a β2-dependent mechanism. |
|---|---|
| References | References 1. Scott JW, et al. Chem Biol. 2015 Jun 18;22(6):705-11. View Related Products by Target AMPK |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 697.3±55.0 °C at 760 mmHg |
| Molecular Formula | C22H14N2O3 |
| Molecular Weight | 354.358 |
| Flash Point | 375.5±31.5 °C |
| Exact Mass | 354.100433 |
| LogP | 5.62 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.797 |
| InChIKey | LXTNNPFHINYWLL-UHFFFAOYSA-N |
| SMILES | N#Cc1c(O)c2cc(-c3ccc(-c4ccccc4O)cc3)ccc2[nH]c1=O |
| 3-Quinolinecarbonitrile, 2,4-dihydroxy-6-(2'-hydroxy[1,1'-biphenyl]-4-yl)- |
| MFCD30802280 |
| 2,4-Dihydroxy-6-(2'-hydroxy-4-biphenylyl)-3-quinolinecarbonitrile |