LY223982

Modify Date: 2025-08-25 19:04:05

Use of LY223982

LY223982 is a potent and specific inhibitor of leukotriene B4 receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor.

Name	[3h]-skf 107324
Synonym	More Synonyms

Description	LY223982 is a potent and specific inhibitor of leukotriene B4 receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology
Target	LTB4:13.2 nM (IC50)
In Vitro	LY223982 is a potent and specific inhibitor of leukotriene B4 (LTB4) receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor. LY223982 is also a potent antagonist of the aggregation of human neutrophils by LTB4 (IC50, 100 nM)[1].
In Vivo	LY223982 inhibits transient leukopenia induced in rabbits with LTB4 (ED50, 3 mg/kg) but not with FMLP, and shows no agonist activity in any of the test systems[1].
References	[1]. Jackson WT, et al. Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982. J Pharmacol Exp Ther. 1992 Dec;263(3):1009-14.

Density	1.2±0.1 g/cm3
Boiling Point	753.8±60.0 °C at 760 mmHg
Molecular Formula	C₃₀H₃₀O₇
Molecular Weight	502.555
Flash Point	248.4±26.4 °C
Exact Mass	502.199158
PSA	110.13000
LogP	6.32
Vapour Pressure	0.0±2.7 mmHg at 25°C
Index of Refraction	1.612
InChIKey	SYZSSLLFRVDRHL-QPJJXVBHSA-N
SMILES	COc1ccc(C=CCCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1
Storage condition	2-8℃

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Price: ￥990/1 mg

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