Israpafant
Modify Date: 2025-08-27 12:05:41
Israpafant structure
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Common Name | Israpafant | ||
|---|---|---|---|---|
| CAS Number | 117279-73-9 | Molecular Weight | 489.07 | |
| Density | 1.26g/cm3 | Boiling Point | 637.3ºC at 760mmHg | |
| Molecular Formula | C28H29ClN4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 339.2ºC | |
Use of IsrapafantIsrapafant (Y-24180) is a potent, selective and long-acting platelet activation factor (PAF) receptor antagonist with IC50s of 0.84 nM and 3.84 nM against PAF-induced human and rabbit platelet aggregation, respectively. Israpafant stimulates both extracellular Ca2+ influx and intracellular Ca2+ release in prostate cancer cells. Israpafant suppresses the allergic cutaneous reactions including eosinophilia, cytokine production, edema and erythema in mice[1][2]. |
| Name | Israpafant |
|---|
| Description | Israpafant (Y-24180) is a potent, selective and long-acting platelet activation factor (PAF) receptor antagonist with IC50s of 0.84 nM and 3.84 nM against PAF-induced human and rabbit platelet aggregation, respectively. Israpafant stimulates both extracellular Ca2+ influx and intracellular Ca2+ release in prostate cancer cells. Israpafant suppresses the allergic cutaneous reactions including eosinophilia, cytokine production, edema and erythema in mice[1][2]. |
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| Related Catalog | |
| Target |
IC50: 0.84 nM (PAF-induced human platelet aggregation), 3.84 nM (PAF-induced rabbit platelet aggregation)[1] |
| References |
| Density | 1.26g/cm3 |
|---|---|
| Boiling Point | 637.3ºC at 760mmHg |
| Molecular Formula | C28H29ClN4S |
| Molecular Weight | 489.07 |
| Flash Point | 339.2ºC |
| Exact Mass | 488.18000 |
| PSA | 71.31000 |
| LogP | 6.62190 |
| Vapour Pressure | 3.83E-16mmHg at 25°C |
| Index of Refraction | 1.667 |
| InChIKey | RMSWMRJVUJSDGN-UHFFFAOYSA-N |
| SMILES | Cc1nnc2n1-c1sc(CCc3ccc(CC(C)C)cc3)cc1C(c1ccccc1Cl)=NC2C |