Israpafant

Modify Date: 2025-08-27 12:05:41

Israpafant Structure
Israpafant structure
Common Name Israpafant
CAS Number 117279-73-9 Molecular Weight 489.07
Density 1.26g/cm3 Boiling Point 637.3ºC at 760mmHg
Molecular Formula C28H29ClN4S Melting Point N/A
MSDS N/A Flash Point 339.2ºC

 Use of Israpafant


Israpafant (Y-24180) is a potent, selective and long-acting platelet activation factor (PAF) receptor antagonist with IC50s of 0.84 nM and 3.84 nM against PAF-induced human and rabbit platelet aggregation, respectively. Israpafant stimulates both extracellular Ca2+ influx and intracellular Ca2+ release in prostate cancer cells. Israpafant suppresses the allergic cutaneous reactions including eosinophilia, cytokine production, edema and erythema in mice[1][2].

 Names

Name Israpafant

 Israpafant Biological Activity

Description Israpafant (Y-24180) is a potent, selective and long-acting platelet activation factor (PAF) receptor antagonist with IC50s of 0.84 nM and 3.84 nM against PAF-induced human and rabbit platelet aggregation, respectively. Israpafant stimulates both extracellular Ca2+ influx and intracellular Ca2+ release in prostate cancer cells. Israpafant suppresses the allergic cutaneous reactions including eosinophilia, cytokine production, edema and erythema in mice[1][2].
Related Catalog
Target

IC50: 0.84 nM (PAF-induced human platelet aggregation), 3.84 nM (PAF-induced rabbit platelet aggregation)[1]

References

[1]. Takehara S, et al. Pharmacological actions of Y-24180, a new specific antagonist of platelet activating factor (PAF): II. Interactions with PAF and benzodiazepine receptors. Prostaglandins. 1990 Dec;40(6):571-83.

[2]. Jan C R, Chao Y Y. Novel effect of Y-24180, a presumed specific platelet activation factor receptor antagonist, on Ca2+ levels and growth of human prostate cancer cells. Cellular signalling, 2004, 16(8): 959-965.

 Chemical & Physical Properties

Density 1.26g/cm3
Boiling Point 637.3ºC at 760mmHg
Molecular Formula C28H29ClN4S
Molecular Weight 489.07
Flash Point 339.2ºC
Exact Mass 488.18000
PSA 71.31000
LogP 6.62190
Vapour Pressure 3.83E-16mmHg at 25°C
Index of Refraction 1.667
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