HLCL-61 (hydrochloride)
Modify Date: 2025-08-25 16:30:25
HLCL-61 (hydrochloride) structure
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Common Name | HLCL-61 (hydrochloride) | ||
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| CAS Number | 1158279-20-9 | Molecular Weight | 380.910 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H25ClN2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HLCL-61 (hydrochloride)HLCL-61 hydrochloride is a first-in-class small-molecule inhibitor of PRMT5. Target: PRMT5in vitro: HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12 h post-treatment and persisting after 48 h. Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also resulted in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h.[1] |
| Name | 1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride (1:1) |
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| Synonym | More Synonyms |
| Description | HLCL-61 hydrochloride is a first-in-class small-molecule inhibitor of PRMT5. Target: PRMT5in vitro: HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12 h post-treatment and persisting after 48 h. Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also resulted in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h.[1] |
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| Related Catalog | |
| References |
| Molecular Formula | C23H25ClN2O |
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| Molecular Weight | 380.910 |
| Exact Mass | 380.165527 |
| InChIKey | XYAVCNMZZKTEGR-UHFFFAOYSA-N |
| SMILES | CCn1c2ccccc2c2cc(CNCc3ccccc3OC)ccc21.Cl |
| Storage condition | -20℃ |
| 1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride (1:1) |
| 9H-Carbazole-3-methanamine, 9-ethyl-N-[(2-methoxyphenyl)methyl]-, hydrochloride (1:1) |
| HLCL-61 hydrochloride |
| HLCL-61 (hydrochloride) |