ER 819762
Modify Date: 2022-09-30 00:29:30
ER 819762 structure
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Common Name | ER 819762 | ||
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| CAS Number | 1155773-15-1 | Molecular Weight | 489.649 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 622.2±65.0 °C at 760 mmHg | |
| Molecular Formula | C30H39N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 330.1±34.3 °C | |
Use of ER 819762ER-819762 is a novel potent, selective, orally active EP4 receptor antagonist with IC50 of 59 nM in cAMP-dependent reporter assay; inhibits EP4-stimulated Th1 differentiation, Th17 cell expansion, and IL-23 secretion by activated dendritic cells; exhibits no agonism or antagonism for the related PGE2 EP1, EP2 and EP3 receptors; suppresses Th1 and Th17 cytokine production, suppresses disease in collagen- and GPI-induced arthritis in mice, and suppresses CFA-induced inflammatory pain in rats. |
| Name | ER819762 |
|---|---|
| Synonym | More Synonyms |
| Description | ER-819762 is a novel potent, selective, orally active EP4 receptor antagonist with IC50 of 59 nM in cAMP-dependent reporter assay; inhibits EP4-stimulated Th1 differentiation, Th17 cell expansion, and IL-23 secretion by activated dendritic cells; exhibits no agonism or antagonism for the related PGE2 EP1, EP2 and EP3 receptors; suppresses Th1 and Th17 cytokine production, suppresses disease in collagen- and GPI-induced arthritis in mice, and suppresses CFA-induced inflammatory pain in rats. |
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| References | References 1. Chen Q, et al. Br J Pharmacol. 2010 May;160(2):292-310. 2. Jones VC, et al. Br J Pharmacol. 2016 Mar;173(6):992-1004. View Related Products by Target Prostaglandin Receptor |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 622.2±65.0 °C at 760 mmHg |
| Molecular Formula | C30H39N3O3 |
| Molecular Weight | 489.649 |
| Flash Point | 330.1±34.3 °C |
| Exact Mass | 489.299133 |
| LogP | 5.20 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.625 |
| (10S)-1'-(3,5-Dimethylbenzyl)-2-ethyl-7,9-dimethoxy-10-methyl-5,10-dihydrospiro[imidazo[1,5-b][2]benzazepine-1,4'-piperidin]-3(2H)-one |
| ER819762 |
| Spiro[1H-imidazo[1,5-b][2]benzazepine-1,4'-piperidin]-3(2H)-one, 1'-[(3,5-dimethylphenyl)methyl]-2-ethyl-5,10-dihydro-7,9-dimethoxy-10-methyl-, (10S)- |