(Arg6,D-Trp7.9,N-Me-Phe8)-Substance P (6-11)

Modify Date: 2025-08-20 06:32:24

(Arg6,D-Trp7.9,N-Me-Phe8)-Substance P (6-11) structure	Common Name	(Arg6,D-Trp7.9,N-Me-Phe8)-Substance P (6-11)
	CAS Number	115150-59-9	Molecular Weight	951.19000
	Density	1.35g/cm3	Boiling Point	N/A
	Molecular Formula	C₄₉H₆₆N₁₂O₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (Arg6,D-Trp7.9,N-Me-Phe8)-Substance P (6-11)

Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy[1][2].

Name	Antagonist G
Synonym	More Synonyms

Description	Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor
In Vitro	Antagonist G (0-100 μM) induces apoptosis is redox-sensitive and caspase-dependently in SCLC cells[2]. Antagonist G activates JNK1 in SCLC cells[2]. Antagonist G is not intrinsically a free radical oxygen donor but stimulates free radical generation specifically within SCLC cells (6.2-fold) and increases the activity of the redox-sensitive transcription factor AP-1 by 61%[2]. Cell Viability Assay[2] Cell Line: SCLC cell lines NCI-H69, NCI-H510 and CHO-K1 cells. Concentration: 0-100 μM. Incubation Time: 24 h. Result: Inhibited cell growh.
References	[1]. P J Woll, et al. A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res. 1990 Jul 1;50(13):3968-73. [2]. A C MacKinnon, et al. [Arg6, D-Trp7,9, NmePhe8]-substance P (6–11) (antagonist G) inducesP-1 transcription and sensitizes cells to chemotherapy. Br J Cancer. 2000 Oct; 83(7): 941–948.

Density	1.35g/cm3
Molecular Formula	C₄₉H₆₆N₁₂O₆S
Molecular Weight	951.19000
Exact Mass	950.49500
PSA	324.60000
LogP	6.47350
Index of Refraction	1.666

arginyl-tryptophyl-n-methylphenylalanyl-tryptophyl-leucyl-methioninamide

AntagonistG,Arg-D-Trp-N-Methyl-Phe-D-Trp-Leu-Met-NH2

ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2

H-ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2

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Shanghai Nianxing Industrial Co., Ltd
China
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GL Biochem (Shanghai) Ltd.
China
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Antagonist G
Price: ￥Inquiry/1g
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DC Chemicals Limited
China
Product Name: Antagonist G
Price: $950.0/100mg $1800.0/250mg $3600.0/1g
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Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Nanjing Peptide Biotech Ltd
China
Product Name: Antagonist G
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
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Delivery: 7 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (AMINOETHYLAMINOMETHYL)PHENETHYLTRIMETHOXYSILANE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
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Email: enquiry@dycnchem.com

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