Olopatadine

Modify Date: 2025-08-20 22:06:51

Olopatadine structure	Common Name	Olopatadine
	CAS Number	113806-05-6	Molecular Weight	337.412
	Density	1.2±0.1 g/cm3	Boiling Point	523.0±50.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₃NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	270.1±30.1 °C

Use of Olopatadine

Olopatadine is an orally active and selective histamine 1 (H1) receptor antagonist and a mast cell stabilizer. Olopatadine prevents immunologically stimulated pro-inflammatory mediator release from human conjunctival mast cells. Olopatadine can be used for researching allergic conjunctivitis[1][2].

Name	Olopatadine
Synonym	More Synonyms

Description	Olopatadine is an orally active and selective histamine 1 (H1) receptor antagonist and a mast cell stabilizer. Olopatadine prevents immunologically stimulated pro-inflammatory mediator release from human conjunctival mast cells. Olopatadine can be used for researching allergic conjunctivitis[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H1 Receptor
In Vitro	Olopatadine inhibits anti-IgE antibody-mediated release of TNF-α from human conjunctival mast cells, and significantly decreases the mast cell supernatant-mediated upregulation of ICAM (intercellular adhesion molecule)-1 on human conjunctival epithelial cells in vitro[2].
References	[1]. Kam KW, et al. Topical Olopatadine in the Treatment of Allergic Conjunctivitis: A Systematic Review and Meta-analysis. Ocul Immunol Inflamm. 2017 Oct;25(5):663-677. [2]. Leonardi A, et al. Olopatadine: a drug for allergic conjunctivitis targeting the mast cell. Expert Opin Pharmacother. 2010 Apr;11(6):969-81.

Density	1.2±0.1 g/cm3
Boiling Point	523.0±50.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₃NO₃
Molecular Weight	337.412
Flash Point	270.1±30.1 °C
Exact Mass	337.167786
PSA	49.77000
LogP	3.14
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.641

(Z)-11-[3-(dime...

CAS#:113806-01-2

~89%

Olopatadine

CAS#:113806-05-6

Literature: WO2006/10459 A1, ; Page/Page column 14-15 ;

11-[(Z)-3-(dime...

CAS#:1123338-92-0

~45%

Olopatadine

CAS#:113806-05-6

Literature: WO2010/89268 A2, ; Page/Page column 13-14 ;

(Z)-11-(3-dimet...

CAS#:951006-73-8

~99%

Olopatadine

CAS#:113806-05-6

Literature: US2007/232814 A1, ; Page/Page column 25; 26 ;

(Z)-11-[3-(dime...

CAS#:1253179-74-6

Olopatadine

CAS#:113806-05-6

Literature: WO2010/121877 A2, ; Page/Page column 25-26 ;

magnesium,N,N-d...

CAS#:19070-16-7

Olopatadine

CAS#:113806-05-6

(E)-Olopatadine

CAS#:113806-06-7

Literature: EP2385045 A1, ;

Precursor 4
CAS#:113806-01-2 (Z)-11-[3-(dime... CAS#:1123338-92-0 11-[(Z)-3-(dime... CAS#:1253179-74-6 (Z)-11-[3-(dime... CAS#:19070-16-7 magnesium,N,N-d...
DownStream 2
CAS#:140462-76-6 Olopatadine Hyd... CAS#:1376615-97-2 Olopatadine Car...

{(11E)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-yl}acetic acid

Dibenz[b,e]oxepin-2-acetic acid, 11-[3-(dimethylamino)propylidene]-6,11-dihydro-, (11E)-

MFCD00865645

KW 4679

Olopatatadine

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Olopatadine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Olopatadine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Olopatadine
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Olopatadine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Olopatadine HCl API
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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