NecroX-7
Modify Date: 2025-09-19 19:08:22
NecroX-7 structure
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Common Name | NecroX-7 | ||
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| CAS Number | 1120333-38-1 | Molecular Weight | 516.676 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 806.2±75.0 °C at 760 mmHg | |
| Molecular Formula | C24H29N3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 441.4±37.1 °C | |
Use of NecroX-7NecroX-7 is a small molecule necrosis modulator and potent antioxidant molecule, which can be bound to some types of radicals and especially NAPQI; inhibits osteoclast differentiation by suppressing NF-κB activity and c-Fos expression, reduces hepatic necrosis secondary to IR injury in vivo; decreases t-BHP- and APAP-induced cell death and ROS/RNS formation in HepG2 human hepatocarcinoma and primary mouse hepatocytes, also protects mice from APAP-induced liver injury and lethality by binding directly to NAPQI. |
| Name | 5-[(1,1-Dioxido-4-thiomorpholinyl)methyl]-N-[1-(methylsulfonyl)-4-piperidinyl]-2-phenyl-1H-indol-7-amine |
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| Synonym | More Synonyms |
| Description | NecroX-7 is a small molecule necrosis modulator and potent antioxidant molecule, which can be bound to some types of radicals and especially NAPQI; inhibits osteoclast differentiation by suppressing NF-κB activity and c-Fos expression, reduces hepatic necrosis secondary to IR injury in vivo; decreases t-BHP- and APAP-induced cell death and ROS/RNS formation in HepG2 human hepatocarcinoma and primary mouse hepatocytes, also protects mice from APAP-induced liver injury and lethality by binding directly to NAPQI. |
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| References | References 1. Choi JM, et al. Transplant Proc. 2010 Nov;42(9):3414-21. 2. Grootaert MO, et al. Atherosclerosis. 2016 Sep;252:166-74. 3. Lee DW, et al. Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H1004-14. 4. Park JH, et al. Antioxid Redox Signal. 2013 May 10;18(14):1713-22. View Related Products by Target Apoptosis Inducer |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 806.2±75.0 °C at 760 mmHg |
| Molecular Formula | C24H29N3O3S |
| Molecular Weight | 516.676 |
| Flash Point | 441.4±37.1 °C |
| Exact Mass | 516.186523 |
| LogP | 2.23 |
| Vapour Pressure | 0.0±2.9 mmHg at 25°C |
| Index of Refraction | 1.691 |
| InChIKey | OXROWZRDUZOTSG-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)N1CCC(Nc2cc(CN3CCS(=O)(=O)CC3)cc3cc(-c4ccccc4)[nH]c23)CC1 |
| Storage condition | 2-8°C |
| 5-[(1,1-Dioxido-4-thiomorpholinyl)methyl]-N-[1-(methylsulfonyl)-4-piperidinyl]-2-phenyl-1H-indol-7-amine |
| 1H-Indol-7-amine, 5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-N-[1-(methylsulfonyl)-4-piperidinyl]-2-phenyl- |