Satigrel
Modify Date: 2025-08-25 20:30:31
Satigrel structure
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Common Name | Satigrel | ||
|---|---|---|---|---|
| CAS Number | 111753-73-2 | Molecular Weight | 337.36900 | |
| Density | 1.195g/cm3 | Boiling Point | 581.6ºC at 760mmHg | |
| Molecular Formula | C20H19NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 305.6ºC | |
Use of SatigrelSatigrel (E5510) is a potent inhibitor of platelet aggregation. Satigrel inhibits collagen- and arachidonic acid-induced platelet aggregation through preventing thromboxane A2 synthesis by selective inhibition of the target enzyme, PGHS1, which exists in platelets. Satigrel inhibits PGHS1 (IC50: 0.081 μM) and PGHS2 (IC50: 5.9 μM). Satigrel is against Type III PDE, Type V and Type II (IC50: 15.7 μM, 39.8 μM and 62.4 μM, respectively)[1]. |
| Name | 4-cyano-5,5-bis(4-methoxyphenyl)pent-4-enoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Satigrel (E5510) is a potent inhibitor of platelet aggregation. Satigrel inhibits collagen- and arachidonic acid-induced platelet aggregation through preventing thromboxane A2 synthesis by selective inhibition of the target enzyme, PGHS1, which exists in platelets. Satigrel inhibits PGHS1 (IC50: 0.081 μM) and PGHS2 (IC50: 5.9 μM). Satigrel is against Type III PDE, Type V and Type II (IC50: 15.7 μM, 39.8 μM and 62.4 μM, respectively)[1]. |
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| Related Catalog | |
| References |
| Density | 1.195g/cm3 |
|---|---|
| Boiling Point | 581.6ºC at 760mmHg |
| Molecular Formula | C20H19NO4 |
| Molecular Weight | 337.36900 |
| Flash Point | 305.6ºC |
| Exact Mass | 337.13100 |
| PSA | 79.55000 |
| LogP | 3.89408 |
| Vapour Pressure | 2.27E-14mmHg at 25°C |
| Index of Refraction | 1.578 |
| InChIKey | GRVCTHTXJDYIHB-UHFFFAOYSA-N |
| SMILES | COc1ccc(C(=C(C#N)CCC(=O)O)c2ccc(OC)cc2)cc1 |
| E5510 |
| 5,5-Bis(4-methoxyphenyl)-4-cyano-4-pentenoic acid |
| Satigrel |
| 4-Cyano-5,5-bis(4-methoxyphenyl)-4-pentenoic acid |
| 4-Pentenoic acid,4-cyano-5,5-bis(4-methoxyphenyl) |
| 4-Pentenoic acid,5,5-bis(4-methoxyphenyl)-4-cyano |