LUF6096
Modify Date: 2024-01-16 14:44:12
LUF6096 structure
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Common Name | LUF6096 | ||
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| CAS Number | 1116652-18-6 | Molecular Weight | 414.32800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H21Cl2N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LUF6096LUF6096, a potent allosteric enhancer of the adenosine A3 receptor, is able to allosterically enhance agonist binding. LUF6096 shows low orthosteric affinity for any of the adenosine receptors. LUF6096 shows protective effects in myocardial ischemia/reperfusion injury[1][2]. |
| Name | N-[2-(3,4-dichloroanilino)quinolin-4-yl]cyclohexanecarboxamide |
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| Synonym | More Synonyms |
| Description | LUF6096, a potent allosteric enhancer of the adenosine A3 receptor, is able to allosterically enhance agonist binding. LUF6096 shows low orthosteric affinity for any of the adenosine receptors. LUF6096 shows protective effects in myocardial ischemia/reperfusion injury[1][2]. |
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| Related Catalog | |
| Target |
adenosine A3 receptor[1] |
| In Vitro | LUF6096 (10 μM; 30-120 min) decreases the dissociation rate of 125I-AB-MECA from the A3 receptor by 2.5 times in CHO cell membranes[1]. LUF6096 (10 μM; pretreated for 15 min) significantly and dramatically enhances the intrinsic activity of Cl-IB-MECA for the inhibition of the forskolin-stimulated cAMP production in CHO cells[1]. |
| In Vivo | LUF6096 (twice i.v. bolus for 0.5 mg/kg or single i.v. bolus for 1 mg/kg) protects against myocardial ischemia/reperfusion injury in dogs[1]. Animal Model: Adult mongrel dogs (15-25 kg) were subjected left anterior descending (LAD) coronary artery occlusion and reperfusion[1] Dosage: Twice i.v. bolus for 0.5 mg/kg or single i.v. bolus for 1 mg/kg Administration: I.v. bolus Result: Produced a marked reduction in infarct size (∼50% reduction) compared with vehicle-treated dogs. |
| References |
| Molecular Formula | C22H21Cl2N3O |
|---|---|
| Molecular Weight | 414.32800 |
| Exact Mass | 413.10600 |
| PSA | 60.74000 |
| LogP | 6.87540 |
| Storage condition | -20°C |
| unii-qxa2220n3t |
| luf-6096 |
| cf-602 |