Lestaurtinib
Modify Date: 2025-08-25 13:35:51
Lestaurtinib structure
|
Common Name | Lestaurtinib | ||
|---|---|---|---|---|
| CAS Number | 111358-88-4 | Molecular Weight | 439.463 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 723.0±60.0 °C at 760 mmHg | |
| Molecular Formula | C26H21N3O4 | Melting Point | 215-220ºC | |
| MSDS | Chinese USA | Flash Point | 391.0±32.9 °C | |
Use of LestaurtinibLestaurtinib (CEP-701;KT-5555) is a multi-kinase inhibitor with potent activity against the Trk family of receptor tyrosine kinases. Lestaurtinib inhibits JAK2, FLT3 and TrkA with IC50s of 0.9, 3 and less than 25 nM, respectively. |
| Name | Lestaurtinib |
|---|---|
| Synonym | More Synonyms |
| Description | Lestaurtinib (CEP-701;KT-5555) is a multi-kinase inhibitor with potent activity against the Trk family of receptor tyrosine kinases. Lestaurtinib inhibits JAK2, FLT3 and TrkA with IC50s of 0.9, 3 and less than 25 nM, respectively. |
|---|---|
| Related Catalog | |
| Target |
JAK2:0.9 nM (IC50) TrkA:25 nM (IC50) FLT3:3 nM (IC50) |
| References |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 723.0±60.0 °C at 760 mmHg |
| Melting Point | 215-220ºC |
| Molecular Formula | C26H21N3O4 |
| Molecular Weight | 439.463 |
| Flash Point | 391.0±32.9 °C |
| Exact Mass | 439.153198 |
| PSA | 88.65000 |
| LogP | 3.37 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.880 |
| InChIKey | UIARLYUEJFELEN-LROUJFHJSA-N |
| SMILES | CC12OC(CC1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O |
| Storage condition | Desiccate at -20°C |
| Stability | Photosensitive |
| Water Solubility | DMSO: >10mg/mL |
|
~81%
Lestaurtinib CAS#:111358-88-4 |
| Literature: Gingrich, Diane E.; Hudkins, Robert L. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2829 - 2831 Title/Abstract Full Text View citing articles Show Details Gingrich, Diane E.; Yang, Shi X.; Gessner, George W.; Angeles, Thelma S.; Hudkins, Robert L. Journal of Medicinal Chemistry, 2005 , vol. 48, # 11 p. 3776 - 3783 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |
| SP 924 |
| Lestaurtinib |
| KT 5555 |
| CEP-701 hydrate |
| CEP-701 |
| (15S,16S,18R)-16-Hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1.0.0.0.0.0]octacosa-1,6,8,10,12,20,22,24,26-nonaen-3-one |
| UNII-DO989GC5D1 |
| 6,9-Epoxy-15H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-15-one, 6,7,8,9,16,17-hexahydro-7-hydroxy-7-(hydroxymethyl)-6-methyl-, (6S,7S,9R)- |